2-Bromopyridine-4-carboxylic acid CAS 66572-56-3
2-Bromopyridine-4-carboxylic acid Basic information
| Product Name: | 2-Bromopyridine-4-carboxylic acid |
| Synonyms: | IFLAB-BB F1926-0035;2-BROMOPYRIDINE-4-CARBOXYLIC ACID;2-BROMOISONICOTINIC ACID;2-BROMO-4-PYRIDINECARBOXYLIC ACID;4-PYRIDINECARBOXYLIC ACID, 2-BROMO-;RARECHEM AL BE 1524;2-bromo-4-picolinic acid;2-BROMO-4-PYRIDINECARBOXYLIC ACID / 2-BROMOISONICOTINIC ACID |
| CAS: | 66572-56-3 |
| MF: | C6H4BrNO2 |
| MW: | 202.01 |
| EINECS: | 626-472-3 |
| Product Categories: | Heterocycle-Pyridine series;Picolinic acid series;blocks;Bromides;Carboxes;Pyridines;pyridine derivative;pharmacetical;Carboxylic Acids;Pyridine;Carboxylic Acids |
| Mol File: | 66572-56-3.mol |
2-Bromopyridine-4-carboxylic acid Chemical Properties
| Melting point | 229-231°C |
| Boiling point | 447.2±30.0 °C(Predicted) |
| density | 1.813±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystals or Crystalline Powder |
| pka | 2.98±0.10(Predicted) |
| color | White |
| BRN | 471895 |
| InChI | InChI=1S/C6H4BrNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10) |
| InChIKey | YBTKGKVQEXAYEM-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=CC(C(O)=O)=C1 |
| CAS DataBase Reference | 66572-56-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-36/37 |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | White to light brown powder |
| Uses | 2-Bromoisonicotinic acid (CAS 66572-56-3) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| Application | 2-Bromopyridine-4-carboxylic acid is a kind of Pyridine carboxylic acid compounds, it can be used in medicine synthesis. |
| Hazard | 2-Bromopyridine-4-carboxylic acid is irritating to the eyes and skin, and may also cause respiratory tract irritation. |
| Health Hazard | Accidental contact with 2-Bromopyridine-4-carboxylic acid causes skin irritation and serious eye irritation. |
| Synthesis | 4926-28-7 66572-56-3 General procedure for the synthesis of 2-bromo-4-pyridinecarboxylic acid from 2-bromo-4-methylpyridine: To a stirred solution of 29.0 g (69 mmol) of 2-bromo-4-methylpyridine dissolved in 150 mL of concentrated sulfuric acid was added batchwise 67.9 g (231 mmol) of potassium dichromate. The reaction was cooled using an ice bath to maintain a constant temperature. After addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was slowly poured into 2 L of ice water and stirred at room temperature for 1 hour. The resulting crystals were collected by filtration, washed with water until the eluent was colorless, and finally dried under vacuum to give 30.0 g (88% yield) of 2-bromo-4-pyridinecarboxylic acid. |
| References | [1] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 17; 18 [2] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 36; 37 [3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458 [4] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 9; 24 [5] Polyhedron, 2016, vol. 118, p. 159 - 170 |
2-Bromopyridine-4-carboxylic acid Preparation Products And Raw materials
| Raw materials | Potassium permanganate-->Potassium dichromate-->2-Bromo-4-methylpyridine |
| Preparation Products | 2-(Trifluoromethyl)isonicotinic acid-->2-PHENYL-ISONICOTINIC ACID-->ETHYL 2-BROMOISONICOTINATE-->2-(5-Acetylthiophen-2-yl)-isonicotinic acid-->2-bromo-4-(1-pyrrolidinylcarbonyl)pyridine(SALTDATA: FREE) |
