2-chloro-5-cyanopyridine CAS 33252-28-7

Introduction：Basic information about 2-chloro-5-cyanopyridine CAS 33252-28-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2-chloro-5-cyanopyridine Basic information

• Product Name: 2-chloro-5-cyanopyridine
• Synonyms: BUTTPARK 37\12-46;2-CHLORO-5-CYANOPYRIDINE;2-CHLOROPYRIDINE-5-CARBONITRILE;3-PYRIDINECARBONITRILE, 6-CHLORO-;6-CHLORO-3-CYANO PYRIDINE;6-CHLORO-3-PYRIDINECARBONITRILE;6-CHLORONICOTINONITRILE;2-Chloro-5-pyridine carbonitrile (6-Chloro nicotinonitrile)
• CAS: 33252-28-7
• MF: C6H3ClN2
• MW: 138.55
• EINECS: 608-851-5
• Product Categories: Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Aromatics;Heterocycles;Aromatics Compounds;Chloropyridines;Halopyridines;blocks;Carboxes;Pyridines;pyridine derivative;Halides;PYRIDINE;Pyridine series
• Mol File: 33252-28-7.mol

2-chloro-5-cyanopyridine Chemical Properties

• Melting point: 116-120 °C(lit.)
• Boiling point: 105-107°C 1mm
• density: 1.33±0.1 g/cm3(Predicted)
• Fp: 105-107°C/1mm
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Ethanol
• form: powder to crystal
• pka: -3.56±0.10(Predicted)
• color: White to Light yellow to Light orange
• BRN: 113867
• InChI: InChI=1S/C6H3ClN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H
• InChIKey: ORIQLMBUPMABDV-UHFFFAOYSA-N
• SMILES: C1=NC(Cl)=CC=C1C#N
• CAS DataBase Reference: 33252-28-7(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn,T,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39-37
• RIDADR: 3276
• WGK Germany: 3
• Hazard Note: Toxic
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29333990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

2-chloro-5-cyanopyridine Usage And Synthesis

Chemical Properties

Yellow to Brown Cryst

Uses

2-Chloro-5-cyanopyridine (cas# 33252-28-7) is a compound useful in organic synthesis.

Uses

6-Chloro-3-pyridinecarbonitrile (2-Chloro-5-cyanopyridine) may be used in the preparation of:

• (6-chloro-3-pyridyl)methylamine
• 2-(N-methyl-N-isopropylamino)-5-cyanopyridine
• S-(5-cyano-2-pyridyl)thiouronium chloride

General Description

6-Chloro-3-pyridinecarbonitrile is a substituted pyridine.

Synthesis

Taking 2-chloro-5-trichloromethylpyridine and ammonium chloride as raw materials, the weight ratio of 2-chloro-5-trichloromethylpyridine to ammonium chloride is 1:1.1 to 1:3, and under the catalyst's catalytic action, the reaction temperature is in the range of 100 to 250??C, and the reaction time is in the range of 1 to 18 hours, to produce 2-chloro-5-cyanopyridine.

2-chloro-5-cyanopyridine Preparation Products And Raw materials

• Raw materials: Ethanol-->Thionyl chloride-->Phosphorus oxitrichloride-->Chloroform-->Ammonium hydroxide-->1,1'-Carbonyldiimidazole-->Mercury-->3-Cyanopyridine-->6-Chloronicotinic acid-->4-Chloro-3-cyanopyridine-->NICOTINONITRILE-1-OXIDE-->Nicotinamide-N-oxide
• Preparation Products: 5-(Aminomethyl)-2-chloropyridine-->6-PHENOXYNICOTINIC ACID-->6-PHENOXYNICOTINOYL CHLORIDE-->6-PHENOXYNICOTINONITRILE-->6-PIPERAZINONICOTINONITRILE-->6-Chloro-2-(trifluoromethyl)nicotinonitrile-->2,5-Pyridinedicarbonitrile(6CI,8CI,9CI)-->3-Pyridinemethanamine,6-methoxy-(9CI)