2-Chloro-6-aminopyrazine CAS 33332-28-4

Introduction：Basic information about 2-Chloro-6-aminopyrazine CAS 33332-28-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2-Chloro-6-aminopyrazine Basic information

• Product Name: 2-Chloro-6-aminopyrazine
• Synonyms: 2-AMINO-6-CHLOROPYRAZINE;6-CHLOROPYRAZIN-2-YLAMINE;6-CHLOROPYRAZIN-2-AMINE;2-chloro-6-aminopyrazine;2-AMINO-6-CHLOROPYRAZINE 98%;TIMTEC-BB SBB005488;6-AMino-2-chloropyrazine;6-Chloro-2-aMinopyrazine
• CAS: 33332-28-4
• MF: C4H4ClN3
• MW: 129.55
• EINECS: 206-027-6
• Product Categories: amine| alkyl chloride;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines;Pyrazine;Pyrazines;Nitrogen cyclic compounds;Amines;blocks
• Mol File: 33332-28-4.mol

2-Chloro-6-aminopyrazine Chemical Properties

• Melting point: 150-152°C
• Boiling point: 282.8±35.0 °C(Predicted)
• density: 1.437±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: Soluble in dimethyl sulfoxide and methanol.
• pka: 0.89±0.10(Predicted)
• form: Solid
• color: Purple
• InChI: InChI=1S/C4H4ClN3/c5-3-1-7-2-4(6)8-3/h1-2H,(H2,6,8)
• InChIKey: JTPXVCKCLBROOJ-UHFFFAOYSA-N
• SMILES: C1(N)=NC(Cl)=CN=C1
• LogP: 0.950
• CAS DataBase Reference: 33332-28-4(CAS DataBase Reference)
• EPA Substance Registry System: 2-Amino-6-chloropyrazine (33332-28-4)

Safety Information

• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-60-37
• WGK Germany: WGK 3
• TSCA: TSCA listed
• HazardClass: IRRITANT
• HS Code: 29339900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

2-Chloro-6-aminopyrazine Usage And Synthesis

Chemical Properties

2-Chloro-6-aminopyrazine is Purple Solid

Uses

2-Chloro-6-aminopyrazine is a disubstituted pyrazine used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Uses

2-Amino-6-chloropyrazine is used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Synthesis

4774-14-5

33332-28-4

General procedure for the synthesis of 2-amino-6-chloropyrazine from 2,6-dichloropyrazine: 2,6-dichloropyrazine (10.0 g, 67.1 mmol) and ammonia (100 mL) were sequentially added to a hydrothermal reactor and reacted at 100 °C for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The filter cake was pulped with hexane (16 mL) to give a final white solid of 8.2 g of 2-amino-6-chloropyrazine in 95.0% yield.

References

[1] Patent: CN107857737, 2018, A. Location in patent: Paragraph 0011-0013; 0021-0023; 0030-0032; 0040-0042; 0049
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8328 - 8342
[3] Patent: WO2013/68755, 2013, A1. Location in patent: Page/Page column 67, 68
[4] Patent: WO2017/5786, 2017, A1. Location in patent: Page/Page column 23; 24
[5] Tetrahedron, 1984, vol. 40, # 24, p. 5081 - 5088

2-Chloro-6-aminopyrazine Preparation Products And Raw materials

• Raw materials: 2,6-Dichloropyrazine
• Preparation Products: 2-Amino-3-chloropyrazine-->3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE-->2-Amino-6-methylpyrazine-->5-Chloroimidazo[1,2-a]pyrazine-->N-(6-Chloro-2-pyrazinyl)acetamide-->6-PHENYLPYRAZIN-2-AMINE