Introduction：Basic information about 2-Chloro-6-methylaniline CAS 87-63-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Chloro-6-methylaniline Basic information
| Product Name: | 2-Chloro-6-methylaniline |
| Synonyms: | benzenamine,2-chloro-6-methyl-;benzenamine,2-chloro-6-methyl-(6-cot);o-Toluidine, 6-chloro-;2-chloro-6-methylbenzenamine;2-Chloro-6-methyl-phenylamine;2-CHLORO-6-METHYLANINILE;BENZENEAMINE,2-CHLORO-6-METHYL-;2-Chloro-6-methylaniline, typically 99% |
| CAS: | 87-63-8 |
| MF: | C7H8ClN |
| MW: | 141.6 |
| EINECS: | 201-759-2 |
| Product Categories: | benzene derivative;Anilines, Aromatic Amines and Nitro Compounds;pharmaceutical |
| Mol File: | 87-63-8.mol |
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2-Chloro-6-methylaniline Chemical Properties
| Melting point | 10-12 °C(lit.) |
| Boiling point | 215 °C(lit.) |
| density | 1.152 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.576(lit.) |
| Fp | 210 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 2.51±0.10(Predicted) |
| form | Oil |
| color | Clear Colourless to Pale Purple |
| Water Solubility | Immiscible |
| BRN | 774624 |
| InChIKey | WFNLHDJJZSJARK-UHFFFAOYSA-N |
| CAS DataBase Reference | 87-63-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenamine, 2-chloro-6-methyl-(87-63-8) |
| EPA Substance Registry System | 6-Chloro-2-methylaniline (87-63-8) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36-36/37/39 |
| RIDADR | UN 3429 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | XU5100000 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29214300 |
2-Chloro-6-methylaniline Usage And Synthesis
| Description | 2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions. |
| Chemical Properties | clear yellow to red-brown liquid |
| Chemical Properties | The chloromethylanilines are colorless orwhite crystalline solids or liquids, some have a mildfishy odor. |
| Uses | 2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate. |
| Preparation | A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction. |
| Potential Exposure | Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to killbirds. It is marketed as pelleted bait for control of birdpopulations. |
| Shipping | UN2239 Chlorotoluidines, solid, Hazard Class:6.1; Labels: 6.1-Poisonous materials. UN3429Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials |
| Incompatibilities | Incompatible with oxidizers, strongacids; chloroformates, and acid anhydrides, isocyanates,aldehydes forming fire and explosive hazards. |
2-Chloro-6-methylaniline Preparation Products And Raw materials
| Raw materials | 4-Chloro-2-methylaniline |
| Preparation Products | 2-AMINO-3-CHLOROBENZOTRIFLUORIDE-->2-CHLORO-6-METHYLBENZALDEHYDE-->1H-Pyrazole-3-carboxylic acid, 4-[(2-chloro-6-methylphenyl)azo]-1-(2-chloro-6-methyl-4-sulfophenyl)-4,5-dihydro-5-oxo-, 3-ethyl ester, sodium salt-->N-(2-CHLORO-6-METHYLPHENYL)FORMAMIDE&-->2-Chloro-4-iodo-6-MethylbenzenaMine-->2,2'-methylenebis[3-chlorotoluene] |
