2-Chlorobenzothiazole CAS 615-20-3
2-Chlorobenzothiazole Basic information
| Product Name: | 2-Chlorobenzothiazole |
| Synonyms: | 2-CHLOROBENZOTHIAZOLE;2-CHLOROBENZO[D]THIAZOLE;2-BENZOTHIAZOLYL CHLORIDE;2-CHLORO-1,3-BENZOTHIAZOLE;2-Chlorobenzophiazole;2-chloro-benzothiazol;USAF ek-2784;usafek-2784 |
| CAS: | 615-20-3 |
| MF: | C7H4ClNS |
| MW: | 169.63 |
| EINECS: | 210-415-0 |
| Product Categories: | BENZOTHIAZOLE;API Intermediate;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiazoles;ThiazolesHeterocyclic Building Blocks |
| Mol File: | 615-20-3.mol |
2-Chlorobenzothiazole Chemical Properties
| Melting point | 21-23 °C (lit.) |
| Boiling point | 141 °C/30 mmHg (lit.) |
| density | 1.303 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | -0.23±0.10(Predicted) |
| color | Clear yellow to yellow-brownish |
| Specific Gravity | 1.3711.303 |
| Water Solubility | insoluble |
| BRN | 116316 |
| InChI | 1S/C7H4ClNS/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H |
| InChIKey | BSQLQMLFTHJVKS-UHFFFAOYSA-N |
| SMILES | Clc1nc2ccccc2s1 |
| CAS DataBase Reference | 615-20-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzothiazole, 2-chloro-(615-20-3) |
| EPA Substance Registry System | 2-Chlorobenzothiazole (615-20-3) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-22-20/21/22 |
| Safety Statements | 23-24/25-37/39-26-36 |
| RIDADR | 2810 |
| WGK Germany | 3 |
| RTECS | DL3150000 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HS Code | 29342080 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Oral Aquatic Chronic 2 Eye Irrit. 2 |
| Chemical Properties | CLEAR YELLOW TO YELLOW-BROWNISH LIQUID |
| Uses | 2-Chloro-1,3-benzothiazole is used in the synthesis of CBTs which are good building blocks for bioluminescent compounds for imaging. |
| Uses | 2-Chlorobenzothiazole was used in the synthesis of:
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| Synthesis | 95-16-9 615-20-3 The general procedure for the synthesis of 2-chlorobenzothiazole from benzothiazole was as follows: benzothiazole (1 mmol, 135.9 mg) and carbon tetrachloride (1.1 mmol, 169.2 mg) were placed in a 10 mL round bottom flask. 5 mL of N,N-dimethylformamide and sodium tert-butoxide (4.0 mmol, 384.4 mg) were added to the reaction system and stirred thoroughly to ensure that the reactants were homogeneously mixed. The reaction was carried out at room temperature for 3 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane. The organic phase was separated and dried with anhydrous sodium sulfate. Subsequently, the dichloromethane was removed by rotary evaporator to obtain the crude product. The crude product was purified by silica gel column chromatography using a mixed solvent of petroleum ether and ethyl acetate as eluent (30:1, v/v). 2-Chlorobenzothiazole (brown oily liquid, 149.2 mg) was finally obtained in 88% yield. |
| Purification Methods | It is purified by fractional distillation in vacuo. The 2-chloro-3-methylbenzothiazolinium 2,4-dinitrobenzenesulfonate crystallises from Ac2O, m 162-163o(dec). [Young & Amstutz J Am Chem Soc 73 4773 1951, Brower et al. J Org Chem 19 1830 1954, Hunter & Jones J Chem Soc 2190 1930, Beilstein 27 H 44, 27 II 18, 27 III/IV 1072.] |
| References | [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 6, p. 886 - 890 [2] Patent: CN107501023, 2017, A. Location in patent: Paragraph 0063; 0064 [3] Organic Letters, 2009, vol. 11, # 2, p. 421 - 423 [4] Journal of Organic Chemistry, 2009, vol. 74, # 21, p. 8309 - 8313 [5] Chemische Berichte, 1880, vol. 13, p. 16 |
2-Chlorobenzothiazole Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Phosphorus oxitrichloride-->Chlorine-->Phosphorus pentachloride-->2-Mercaptobenzothiazole-->2-((Difluoromethyl)sulfonyl)benzo[d]thiazole, 98%-->PHENYL ISOCYANIDE DICHLORIDE-->ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE-->2-HYDRAZINOBENZOTHIAZOLE-->Phenyl isothiocyanate-->Ethyl trichloroacetate-->Aniline |
| Preparation Products | (2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+%-->2,2'-METHYLENEBISBENZOTHIAZOLE-->(-)-Benzotetramisole-->2-IODOBENZOTHIAZOLE-->2(3H)-Benzothiazoleselone(9CI) |
