2-Chloro-N-(2,6-dimethylphenyl)acetamide CAS 1131-01-7
2-Chloro-N-(2,6-dimethylphenyl)acetamide Basic information
| Product Name: | 2-Chloro-N-(2,6-dimethylphenyl)acetamide |
| Synonyms: | Chloro-2',6'-diMethylacetanilide;2',6'-DiMethyl-2-chloroacetanilide;ChloroacetaMido-2,6-xylidine;N-(2,6-Xylyl)chloroacetaMide;NSC 37260;2-Chloro-N-(2,6-dimethylphenyl)acetamide2-Chloro-N-(2,6-dimethylphenyl)acetamide;2-Chloro-N-(2;6-diMethylphenyl)acetaMide |
| CAS: | 1131-01-7 |
| MF: | C10H12ClNO |
| MW: | 197.66 |
| EINECS: | 214-460-7 |
| Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amides;Carbonyl Compounds;Organic Building Blocks |
| Mol File: | 1131-01-7.mol |
2-Chloro-N-(2,6-dimethylphenyl)acetamide Chemical Properties
| Melting point | 150-151 °C(lit.) |
| Boiling point | 316.8±30.0 °C(Predicted) |
| density | 1.1363 (rough estimate) |
| refractive index | 1.5330 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 12.91±0.70(Predicted) |
| form | Crystalline Powder or Needles |
| color | White to brown |
| Water Solubility | Soluble in Chloroform, Methanol. Insoluble in water. |
| BRN | 781309 |
| Stability: | Light Sensitive |
| InChI | 1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13) |
| InChIKey | FPQQSNUTBWFFLB-UHFFFAOYSA-N |
| SMILES | Cc1cccc(C)c1NC(=O)CCl |
| CAS DataBase Reference | 1131-01-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chloro-2',6'-acetoxylidide(1131-01-7) |
| EPA Substance Registry System | Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- (1131-01-7) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 29214200 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | beige needles or crystalline powder |
| Uses | Lidocaine intermediate. |
| Uses | 2-Chloro-2',6'-dimethylacetanilide is used in the determination of the enantiomers of tocainide in blood plasma by gas-liquid chromatography with electron-capture detection. It is a nonsteroidal antinflammatory drug. |
| General Description | N-(2,6-Dimethylphenyl)chloroacetamide (2-chloro-2′,6′-acetoxylidide) is nonsteroidal antinflammatory drug. |
| Synthesis | 593-71-5 28556-81-2 1131-01-7 General method: Chloroiodomethane (1.5 eq.) is slowly added to a solution of 2,6-dimethylphenyl isocyanate (1.0 eq.) in anhydrous ether (1 M concentration) at -78 °C. After 2 minutes of reaction, a 1.5 M solution of methyl lithium-lithium bromide (1.25 equiv.) ether was added dropwise over 5 minutes. Maintaining this temperature, the reaction mixture was stirred for the indicated time (see Table 1 and Scheme 2 for specific times). Upon completion of the reaction, aqueous ammonium chloride solution (2 mL/mmol substrate) was added, the cooling bath was removed, and stirring was continued until the mixture was brought to room temperature. Subsequently, the reaction mixture was extracted with ether (2 x 5 mL) and the organic phase was washed sequentially with water (5 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give pure 2,6-dimethylchloroacetanilide. |
| References | [1] Chemical Communications, 2013, vol. 49, # 75, p. 8383 - 8385 [2] Synthesis (Germany), 2014, vol. 46, # 21, p. 2897 - 2909 |
2-Chloro-N-(2,6-dimethylphenyl)acetamide Preparation Products And Raw materials
| Raw materials | Chloroacetyl chloride-->N-Methylaniline-->Chloroiodomethane-->2,6-Dimethylaniline-->2,6-Dimethyl-1-nitrobenzene-->2,6-Dimethylphenyl isocyanate-->Sodium acetate-->Sodium bicarbonate-->Chloroacetic anhydride |
| Preparation Products | Pyrazole-->Nefiracetam-->Lidocaine Impurity |
