2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl CAS 224311-49-3

Introduction：Basic information about 2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl CAS 224311-49-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Basic information

• Product Name: 2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl
• Synonyms: 2'-[Bis(1,1-dimethylethyl)phosphino]-N,N-dimethyl-[1,1'-biphenyl]-2-amine;2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl,98%;2-[2-(di-tert-butylphosphanyl)phenyl]-N,N-diMethylaniline;98% tBuDavePhos;2-(Di-tert-butylphosphiNA)-2'-(N,N-diMethylaMiNA)biphenyl;2-(Di-tert-butylphosphino)-2'-;2-Di-t-butylphosphino-2'-(N,N-diMethylaMino)biphenyl,98% tBuDavePhos;t-BuDavePhos 97%
• CAS: 224311-49-3
• MF: C22H32NP
• MW: 341.47
• EINECS: 607-073-3
• Product Categories: Phosphines;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts
• Mol File: 224311-49-3.mol

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties

• Melting point: 115-117 °C
• Boiling point: 451.6±38.0 °C(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• form: crystal
• pka: 5.07±0.18(Predicted)
• color: white
• Sensitive: Air Sensitive
• InChI: InChI=1S/C22H32NP/c1-21(2,3)24(22(4,5)6)20-16-12-10-14-18(20)17-13-9-11-15-19(17)23(7)8/h9-16H,1-8H3
• InChIKey: PHLPNEHPCYZBNZ-UHFFFAOYSA-N
• SMILES: C1(C2=CC=CC=C2P(C(C)(C)C)C(C)(C)C)=CC=CC=C1N(C)C

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• TSCA: No
• HS Code: 29319090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 4 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Usage And Synthesis

Reaction

1. Useful ligand for Pd-catalyzed carbon-oxygen bond forming reactions.
2. Ligand used selective Pd-catalyzed arylation of ammonia. Application to the synthesis of dibenzodiazepines.
3. Ligand used for selective Pd-catalyzed silylation of aryl chlorides.
4. Ligand used for Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes. 

Chemical Properties

White crystals or crystalline powder

Uses

suzuki reaction

reaction suitability

reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation

Synthesis

The target compound 2-di-tert-butylphosphine-2-(N,N-dimethylamino)biphenyl was prepared by the Suzuki reaction using 2-bromochlorobenzene as starting material, followed by the reaction with di-tert-butylphosphonium chloride.

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

• Preparation Products: Methanesulfonato2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)