Introduction：Basic information about 2-Ethoxybenzamide CAS 938-73-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Ethoxybenzamide Basic information
| Product Name: | 2-Ethoxybenzamide |
| Synonyms: | 2-ethoxy-benzamid;Salicylamideo-ethylether;Trancalgyl;ETHENZAMIDE;2-ETHOXYBENZAMIDE;2-ETHOXYBENZOYLAMIDE;ETHENZAMIDE/ETHOXYBENZAMIDE;2-ETHOXYBENZAMIDE(ETHENZAMIDE) |
| CAS: | 938-73-8 |
| MF: | C9H11NO2 |
| MW: | 165.19 |
| EINECS: | 213-346-4 |
| Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;API's;Amides;Carbonyl Compounds;Organic Building Blocks |
| Mol File: | 938-73-8.mol |
|
2-Ethoxybenzamide Chemical Properties
| Melting point | 132-134 °C (lit.) |
| Boiling point | 293.03°C (rough estimate) |
| density | 1.1603 (rough estimate) |
| refractive index | 1.5620 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly) |
| pka | 15.62±0.50(Predicted) |
| form | Granular Crystalline Powder |
| color | White to almost white |
| Water Solubility | <0.1 g/100 mL at 16 ºC |
| Merck | 14,3731 |
| InChI | InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11) |
| InChIKey | SBNKFTQSBPKMBZ-UHFFFAOYSA-N |
| SMILES | C(N)(=O)C1=CC=CC=C1OCC |
| CAS DataBase Reference | 938-73-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethenzamide(938-73-8) |
| EPA Substance Registry System | Ethenzamide (938-73-8) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | CU4381000 |
| TSCA | TSCA listed |
| HS Code | 29242995 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 orally in mice: 1160 mg/kg (Starmer) |
2-Ethoxybenzamide Usage And Synthesis
| Chemical Properties | WHITE TO ALMOST WHITE GRANULAR CRYSTALLINE POWDER |
| Originator | Ethenzamide,Tongxiang Hengda |
| Definition | ChEBI: Ethenzamide is an organic molecular entity. |
| Manufacturing Process | 500 g of salicylic amide are dissolved in 1.5 L of 10% alcohol by means of146 g of sodium hydroxide. 560 g diethyl sulphate are added, the mixture isfrequently shaken during four hours and kept cold. 20 hours later the 2-ethoxy-benzamide is precipitated in a gritty state and is removed by suctionand dried at 50°-100°C. The yield is 540 g or about 90%. MP: 130°C. |
| Therapeutic Function | Analgesic |
| General Description | White or almost-white crystalline powder. Almost odorless. Tasteless. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | 2-Ethoxybenzamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
| Health Hazard | ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-Ethoxybenzamide emits toxic fumes of nitrogen oxides. |
| Fire Hazard | Flash point data for 2-Ethoxybenzamide are not available; however, 2-Ethoxybenzamide is probably combustible. |
| Clinical Use | Ethenzamide is a nonsteroidalanti-inflammatory drug used mainly in combinationwith other ingredients for the treatment ofmild to moderate pain including musculoskeletaland joint disorders. |
| References | [1] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4090 - 4093
[2] Journal of Organic Chemistry, 2015, vol. 80, # 8, p. 4148 - 4151
[3] ChemCatChem, 2017, vol. 9, # 7, p. 1349 - 1353
[4] Patent: CN106588686, 2017, A. Location in patent: Paragraph 0023; 0025 |
2-Ethoxybenzamide Preparation Products And Raw materials
| Raw materials | Bromoethane-->CHLOROETHANE-->Salicylamide-->Diethyl sulfate-->Benzamide, 2-(ethenyloxy)- (9CI)-->2-ETHOXY-1-ETHYNYL-BENZENE-->2-Ethoxybenzaldehyde-->2'-Ethoxyacetophenone-->2-NITROBENZAMIDE-->4-Ethoxybenzamide-->2-Fluorobenzamide-->2-Ethoxybenzonitrile-->Salicylhydrazide-->Phenetole-->Salicylaldoxime |
| Preparation Products | 2-Ethoxybenzoic acid |
