2-Methyl-5-nitroanisole CAS 13120-77-9
2-Methyl-5-nitroanisole Basic information
| Product Name: | 2-Methyl-5-nitroanisole |
| Synonyms: | 2-methoxy-1-methyl-4-nitro-benzen;1-METHOXY-2-METHYL-5-NITROBENZENE;2-METHYL-5-NITROANISOLE;2-METHOXY-4-NITROTOLUENE;2-METHOXY-1-METHYL-4-NITRO-BENZENE;1-Methoxy-2-methyl-5-nitrobenzene2-Methyl-5-nitroanisole;4-nitro-2-Methoxytoluene;2-METHYL-5-NITROANISOLE 99% |
| CAS: | 13120-77-9 |
| MF: | C8H9NO3 |
| MW: | 167.16 |
| EINECS: | 236-048-6 |
| Product Categories: | Aromatic Hydrocarbons (substituted) & Derivatives;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Nitro Compounds;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 13120-77-9.mol |
2-Methyl-5-nitroanisole Chemical Properties
| Melting point | 69-71 °C (lit.) |
| Boiling point | 281.2±20.0 °C(Predicted) |
| density | 1.180±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | 1S/C8H9NO3/c1-6-3-4-7(9(10)11)5-8(6)12-2/h3-5H,1-2H3 |
| InChIKey | WVQGZNRUEVFXKR-UHFFFAOYSA-N |
| SMILES | COc1cc(ccc1C)[N+]([O-])=O |
| CAS DataBase Reference | 13120-77-9(CAS DataBase Reference) |
| EPA Substance Registry System | Benzene, 2-methoxy-1-methyl-4-nitro- (13120-77-9) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HS Code | 29093090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Uses | 2-Methyl-5-nitroanisole is a useful research chemical. |
| Chemical Properties | cream to yellow crystalline powder and chunks |
| Uses | 2-Methyl-5-nitroanisole was used in the synthesis of:
|
| Synthesis | 5428-54-6 74-88-4 13120-77-9 GENERAL METHOD: Under argon protection, 2-methyl-5-nitrophenol (613 mg, 4.0 mmol) was dissolved in anhydrous DMF (7 mL) and potassium carbonate (608 mg, 4.4 mmol) and iodomethane (12.0 mmol) were added sequentially. The reaction mixture was heated with stirring at 40 °C for 2-3 hours. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography to afford the target product 2-methyl-5-nitroanisole. |
| References | [1] European Journal of Organic Chemistry, 2009, # 27, p. 4614 - 4621 [2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3156 - 3172 [3] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988 [4] Patent: US2004/214798, 2004, A1. Location in patent: Page 18 |
2-Methyl-5-nitroanisole Preparation Products And Raw materials
| Raw materials | 2-Methyl-5-nitrophenol-->Iodomethane-->N,N-Dimethylformamide-->Potassium carbonate |
| Preparation Products | 3-methoxy-4-methylphenol-->2-METHOXY-4-NITROBENZALDEHYDE-->3-METHOXY-4-METHYLANILINE-->2-Methoxy-4-aminobenzaldehyde-->5-Nitro-4-dimethylamino-2-methoxybenzonium acid |
