Introduction：Basic information about 2-PIPERIDYLMETHYLAMINE CAS 22990-77-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-PIPERIDYLMETHYLAMINE Basic information
| Product Name: | 2-PIPERIDYLMETHYLAMINE |
| Synonyms: | 1-(Piperidin-2-yl)methylamine;1-piperidin-2-ylmethanamine;2-AMINOMETHYL PIPERIDINE 99%;piperidin-2-ylmethanamine;2-PIPERIDYLMETHYLAMI;2 - Methyl piperidine aMMonia;(RS)-1-(Piperidin-2-yl)methanamine;2-Amino-methyl-priperidine |
| CAS: | 22990-77-8 |
| MF: | C6H14N2 |
| MW: | 114.19 |
| EINECS: | 245-371-1 |
| Product Categories: | Piperidine;Amines;Piperidines, Piperidones, Piperazines;Piperazine;Building Blocks;Heterocyclic Building Blocks;Piperidines |
| Mol File: | 22990-77-8.mol |
|
2-PIPERIDYLMETHYLAMINE Chemical Properties
| Boiling point | 63-66°C/12mm |
| density | 0.9406 g/mL at 25 °C |
| refractive index | 1.4850 |
| Fp | 63-66°C/12mm |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 10.32±0.29(Predicted) |
| color | Clear Colorless |
| BRN | 102994 |
| InChI | InChI=1S/C6H14N2/c7-5-6-3-1-2-4-8-6/h6,8H,1-5,7H2 |
| InChIKey | RHPBLLCTOLJFPH-UHFFFAOYSA-N |
| SMILES | N1CCCCC1CN |
| CAS DataBase Reference | 22990-77-8(CAS DataBase Reference) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | 2735 |
| WGK Germany | 2 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29333990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
2-PIPERIDYLMETHYLAMINE Usage And Synthesis
| Uses | 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial. |
| Uses | Reactant for reversible aminal formation
Reactant for synthesis of:
- Annulated N-heterocyclic carbene ligands
- M3 Muscarinic receptor antagonists
- Selective 5-ht5A receptor antagonists
- Ternary platinum(II) complexes
|
| Purification Methods | Dry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.] |
2-PIPERIDYLMETHYLAMINE Preparation Products And Raw materials
| Raw materials | 2-Picolylamine-->Diethyl ether-->Water-->Hydrochloric acid-->2-Cyanopyridine |
| Preparation Products | Flecainide |
