3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE CAS 36499-49-7

Introduction：Basic information about 3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE CAS 36499-49-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE Basic information

• Product Name: 3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE
• Synonyms: 3-[4-(Diethylamino)-2-methylphenyl]-3-(1,2-dimethyl-1H-indol-3-yl)phthalide;3-[4-(Diethylamino)-2-methylphenyl]-3-(1,2-dimethyl-1H-indole-3-yl)-1(3H)-isobenzofuranone;3-(4-(diethylaMino)-2-Methylphenyl)-3-(1,2-diMethyl-1H-indol-3-yl)isobenzofuran-1(3H)-one;2-(2'-Methyl-4'-diethylaminophenyl)-3-(1',2'-dimethylindol-3'-yl)phthalide;3-[2-Methyl-4-(diethylamino)phenyl]-3-(1,2-dimethyl-3-indolyl)phthalide;MB3;3-[2-Methyl-4-(diethylamino)phenyl]-3-(1,2-dimethyl-3-indolyl)phthalide 2-(2'-Methyl-4'-diethylaminophenyl)-3-(1',2'-dimethylindol-3'-yl)phthalide;(2R,3S)-rel-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
• CAS: 36499-49-7
• MF: C29H30N2O2
• MW: 438.56
• Product Categories: Color Former;Color Former & Related Compounds;Functional Materials
• Mol File: 36499-49-7.mol

3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE Chemical Properties

• Melting point: 217 °C
• Boiling point: 627.3±55.0 °C(Predicted)
• density: 1.14
• storage temp.: -20°C
• solubility: H₂O: ≥10 mg/mL || DMSO: ≥20 mg/mL
• form: powder to crystal
• pka: 6.27±0.50(Predicted)
• color: White to Light yellow
• Water Solubility: H2O: ≥10mg/mL DMSO: ≥20mg/mL
• InChI: 1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
• InChIKey: SRQUTZJZABSZRQ-RQJHMYQMSA-N
• SMILES: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

Safety Information

• WGK Germany: nwg
• HS Code: 2933.99.8290
• Storage Class: 11 - Combustible Solids

3-(1,2-DIMETHYL-3-INDOLYL)-3-[4-(DIETHYLAMINO)-2-METHYLPHENYL]PHTHALIDE Usage And Synthesis

Uses

MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor:

• to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations
• to analyze its effects on the growth of Arabidopsis thaliana seedlings
• to study its effects on craniofacial chondrocyte maturation

Biological Activity

MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast. It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5.', 'MB-3 is a Gcn5 H at (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic.