3,3'-Dimethoxybenzidine dihydrochloride CAS 20325-40-0
Introduction：Basic information about 3,3'-Dimethoxybenzidine dihydrochloride CAS 20325-40-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3,3'-Dimethoxybenzidine dihydrochloride Basic information
| Product Name: | 3,3'-Dimethoxybenzidine dihydrochloride |
| Synonyms: | 3,3’-dimethoxy-4,4’-diaminobiphenyldihydrochloride;3,3’-dimethoxy-benzidindihydrochloride;3,3-dimethoxybiphenyl-4,4-ylenediammonium dichloride;ortho-dianisidine dihydrochloride;O-DIANISIDINE DIHYDROCHLORIDE 10 MG*TABL ETS, TRU-ME;3,3'-DIMETHOXYBENZIDINE HYDROCHLORIDE HY DRATE;3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE, PGE WITH 50 TABL.;2-Dianisidinedi2HCl |
| CAS: | 20325-40-0 |
| MF: | C14H17ClN2O2 |
| MW: | 280.75 |
| EINECS: | 243-737-5 |
| Product Categories: | Biphenyl & Diphenyl ether |
| Mol File: | 20325-40-0.mol |
3,3'-Dimethoxybenzidine dihydrochloride Chemical Properties
| Melting point | 268 °C |
| Fp | 206℃ |
| storage temp. | 2-8°C |
| solubility | H2O: soluble25mg/mL |
| form | tablet |
| color | Light beige to purple-gray |
| PH | 1.7 at 20℃ and 100g/L |
| Water Solubility | 1-5 g/100 mL at 20 ºC |
| BRN | 3917996 |
| Major Application | diagnostic assay manufacturing hematology histology |
| InChI | InChI=1S/C14H16N2O2.ClH/c1-17-13-7-9(3-5-11(13)15)10-4-6-12(16)14(8-10)18-2;/h3-8H,15-16H2,1-2H3;1H |
| InChIKey | UXTIAFYTYOEQHV-UHFFFAOYSA-N |
| SMILES | O(C1=C(C=CC(C2C=CC(N)=C(OC)C=2)=C1)N)C.Cl |
| CAS DataBase Reference | 20325-40-0(CAS DataBase Reference) |
| EPA Substance Registry System | 3,3'-Dimethoxybenzidine dihydrochloride (20325-40-0) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 45-22 |
| Safety Statements | 53-45 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | DD1050000 |
| TSCA | TSCA listed |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29222990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral Carc. 1B Eye Dam. 1 Skin Corr. 1 |
| Description | o-Dianisidine (dihydrochloride) is a colorimetric peroxidase substrate that has been used as a substrate to semi-quantitatively measure lactate, uric acid , and glucose. It has also been used as a reagent for the detection of various metals, thiocyanates, and nitrites. This aromatic amine is initially colorless but turns to violet upon oxidization and is spectrophotometrically measured at a wavelength of 405 nm. |
| Chemical Properties | Off-white or grey tablets |
| Uses | o-Dianisidine (3,3′-dimethoxybenzidine) has been used as a component of GO (glucose oxidase) reagent, which is used for measuring the glucose content. It has also been used as a substrate to measure myeloperoxidase activity. |
| Uses | It is suitable for use in ELISA procedures. In neurohistochemistry o-Dianisidine dihydrochloride has demonstrated perikaryal labeling as well as retrograde and anterograde transport to the primary olfactory cortex. It has also been used for a paper based-micro fluidic device to semi-quantitatively measure lactate, uric acid, and glucose. 3,3'-Dimethoxybenzidine is used principally as an intermediate in the production of commercial bisazobiphenyl dyes for coloring textiles, paper, plastic, rubber, and leather. |
| General Description | Off-white powder. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | 3,3'-Dimethoxybenzidine dihydrochloride is an ether substituted acidic organic salt. Reacts weakly as a acid to neutralize bases. May react with strong oxidizing agents or strong reducing agents. |
| Fire Hazard | Flash point data are not available for 3,3'-Dimethoxybenzidine dihydrochloride, but 3,3'-Dimethoxybenzidine dihydrochloride is probably combustible. |
| Safety Profile | Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental reproductive data. Mutation data reported.When heated to decomposition it emits very toxic fumes of NO, and HCl. |
| References | [1] MAMORU SUGIURA Kazuyuki H. A new colorimetric method for determination of serum glucose[J]. Clinica Chimica Acta, 1977, 75 3: Pages 387-391. DOI: 10.1016/0009-8981(77)90357-6 [2] M M MESULAM D L R. Sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods.[J]. Journal of Histochemistry & Cytochemistry, 1979, 27 3: 763-773. DOI: 10.1177/27.3.113450 [3] 3,3’-Dimethoxybenzidine and dyes metabolized to 3,3’-dimethoxybenzidine: 3,3’-dimethoxybenzidine.[J]. Report on carcinogens?: carcinogen profiles, 2011, 12: 164-165. |
3,3'-Dimethoxybenzidine dihydrochloride Preparation Products And Raw materials
| Preparation Products | Nitrotetrazolium blue chloride-->disodium 3-[[4'-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-1-sulphonate-->DIRECT BLUE 15 |
