3,4-Difluoroaniline CAS 3863-11-4
3,4-Difluoroaniline Basic information
| Product Name: | 3,4-Difluoroaniline |
| Synonyms: | 3,4-Difluoroaniline, 99+% 2.5ML;Linezolid Aniline Impurity;Linezolid Impurity 95;3,4-Difluoroaniline 98%, 4-Difluoroaniline 98%;3, 4-2 fluoro aniline;TIMTEC-BB SBB007915;3,4-DIFLUOROANILINE;3,4-DIFLUOROBENZENAMINE |
| CAS: | 3863-11-4 |
| MF: | C6H5F2N |
| MW: | 129.11 |
| EINECS: | 223-381-7 |
| Product Categories: | Nitrogen Compounds;Amines;C2 to C6;Anilines, Amides & Amines;Fluorine Compounds;Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene Series;Fluorine series;bc0001 |
| Mol File: | 3863-11-4.mol |
3,4-Difluoroaniline Chemical Properties
| Melting point | 22°C |
| Boiling point | 77 °C/7 mmHg (lit.) |
| density | 1.302 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 185 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 3?+-.0.10(Predicted) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Yellow |
| Specific Gravity | 1.302 |
| Water Solubility | SLIGHTLY SOLUBLE |
| BRN | 971235 |
| InChI | InChI=1S/C6H5F2N/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2 |
| InChIKey | AXNUZKSSQHTNPZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(F)C(F)=C1 |
| CAS DataBase Reference | 3863-11-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,4-Difluoroaniline(3863-11-4) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-20/21/22 |
| Safety Statements | 26-36-36/37/39 |
| RIDADR | UN 2941 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CX9871900 |
| F | 8-10-23 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29214200 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | clear yellow to straw liquid after melting |
| Uses | 3,4-Difluoroaniline was used in the synthesis of (3,4-disfluoro)phenylquione. |
| General Description | 3,4-Difluoroaniline (3,4-DFA) was degraded, under aerobic conditions, by Pseudomonas fluorescens. |
| Synthesis | 369-34-6 3863-11-4 The general procedure for the synthesis of 3,4-difluoroaniline from 3,4-difluoronitrobenzene was as follows: 200.0 g of 3,4-difluoronitrobenzene, 600.0 mL of toluene and 12.0 g of Pd/C catalyst were added to an autoclave at 25 °C to 35 °C. Hydrogen was passed into the reaction system, keeping the hydrogen pressure between 2.0 and 6.0 kg/cm2, and the reaction was carried out at 25 °C to 35 °C for 3 to 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) to ensure complete reaction. Upon completion of the reaction, the reaction mixture was sequentially depressurized and unloaded, filtered through a Hyflow bed, and the filter cake was washed with 200.0 mL of toluene. The filtrate was collected and vacuum distilled at less than 50 °C to remove the solvent. Finally, 152.0 g of crude 3,4-difluoroaniline was obtained in 93.8% yield and 95.85% purity by high performance liquid chromatography (HPLC). |
| References | [1] Patent: WO2015/68171, 2015, A1. Location in patent: Page/Page column 9; 16 [2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789 [3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 613 - 617 [4] ChemPlusChem, 2018, vol. 83, # 5, p. 375 - 382 [5] Synthesis, 2001, # 1, p. 81 - 84 |
3,4-Difluoroaniline Preparation Products And Raw materials
| Raw materials | Iron-->benzyl 3,4-difluorophenylcarbaMate-->3,4-Difluoronitrobenzene-->Hydrogen-->Toluene-->Palladium-->Activated carbon |
| Preparation Products | 4,5-Difluoroindoline-2,3-dione-->5,6-difluoro-indoline-2,3-dione-->Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate-->5,6-Difluoro-2-oxoindole-->5,6-Difluoroindole-->PIVALAMIDE-->Carbamic acid,(3,4-difluorophenyl)-, ethyl ester (9CI)-->N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE-->(3,4-difluorophenyl)-carbamic acid-tert-butyl ester |
