3-Amino-4-methylphenol CAS 2836-00-2
Introduction：Basic information about 3-Amino-4-methylphenol CAS 2836-00-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3-Amino-4-methylphenol Basic information
| Product Name: | 3-Amino-4-methylphenol |
| Synonyms: | 3-amino-p-cresol;3-AMINO-4-METHYLPHENOL;5-Hydroxy-o-toluidine;2-AMINO-4-HYDROXYTOLUENE;5-Hydroxy-2-methylaniline;m-Amino-p-cresol;2-aMino-4-hydroxytoluene, 98%+;3-Amino-4-Methylphenol 98% |
| CAS: | 2836-00-2 |
| MF: | C7H9NO |
| MW: | 123.15 |
| EINECS: | 220-622-8 |
| Product Categories: | pharmacetical;Phenol&Thiophenol&Mercaptan |
| Mol File: | 2836-00-2.mol |
3-Amino-4-methylphenol Chemical Properties
| Melting point | 156-157°C |
| Boiling point | 229.26°C (rough estimate) |
| density | 1.0877 (rough estimate) |
| refractive index | 1.5706 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 10.32±0.18(Predicted) |
| form | powder to crystal |
| color | Light yellow to Brown to Dark green |
| CAS DataBase Reference | 2836-00-2(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Amino-4-methylphenol (2836-00-2) |
Safety Information
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2922290090 |
| General Description | Crystals. |
| Air & Water Reactions | 3-Amino-4-methylphenol may be sensitive to prolonged exposure to air. |
| Reactivity Profile | 3-Amino-4-methylphenol reacts with strong oxidizing agents. |
| Fire Hazard | Flash point data for 3-Amino-4-methylphenol are not available. 3-Amino-4-methylphenol is probably combustible. |
| Synthesis | 2042-14-0 2836-00-2 The general procedure for the synthesis of 3-amino-4-methylphenol from 4-methyl-3-nitrophenol was as follows: 4-methyl-3-nitrophenol (77 mg, 0.50 mmol), Fe nanoparticles (6 mg), and NaBH4 (29 mg, 0.75 mmol) were placed in 1.0 mL of 2 wt. % TPGS/H2O solution, and the reaction was carried out for 2 h at room temperature. Upon completion of the reaction, 56 mg (91% yield) of 3-amino-4-methylphenol was obtained as a white solid (hexane/ethyl acetate = 50:50). The melting point of the product was 154°C-156°C. It was analyzed by GC-MS with m/z of 123 [M], and the spectral data were consistent with those reported in the literature. |
| References | [1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 240 - 244 [2] Green Chemistry, 2017, vol. 19, # 3, p. 809 - 815 [3] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1964 - 1978 [4] ACS Catalysis, 2017, vol. 7, # 4, p. 2412 - 2418 [5] Patent: WO2018/208132, 2018, A1. Location in patent: Paragraph 704-708 |
3-Amino-4-methylphenol Preparation Products And Raw materials
| Raw materials | 4-Methyl-3-nitrophenol |
| Preparation Products | Benzenesulfonic acid, 5-[(4-amino-2-hydroxy-5-methylphenyl)azo]-2-[4-[(4-amino-2-hydroxy-5-methylphenyl)azo]phenoxy]-, monosodium salt-->Basic Red 4-->rhodamine 3G-->N-(5-hydroxy-2-methylphenyl)acetamide |
