3-Chloropropylamine hydrochloride CAS 6276-54-6
3-Chloropropylamine hydrochloride Basic information
| Product Name: | 3-Chloropropylamine hydrochloride |
| Synonyms: | 3-AMINOPROPYL CHLORIDE HYDROCHLORIDE;3-CHLORPROPYLAMINE HYDROCHLORIDE;3-CHLOROPROPYLAMINE HCL;3-CHLOROPROPYLAMINE HYDROCHLORIDE;3-chloropropylammonium chloride;1-amino-3-chloropropane hydrochloride;1-Propanamine, 3-chloro-, hydrochloride;3-Chloropropylaminehydrocloride |
| CAS: | 6276-54-6 |
| MF: | C3H9Cl2N |
| MW: | 130.02 |
| EINECS: | 228-474-6 |
| Product Categories: | omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;omega-Haloalkylamines;bc0001 |
| Mol File: | 6276-54-6.mol |
3-Chloropropylamine hydrochloride Chemical Properties
| Melting point | 145-150 °C(lit.) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder or Chunks |
| color | Off-white to yellow-beige |
| BRN | 3667451 |
| InChI | InChI=1S/C3H8ClN.ClH/c4-2-1-3-5;/h1-3,5H2;1H |
| InChIKey | IHPRVZKJZGXTBQ-UHFFFAOYSA-N |
| SMILES | C(CCl)CN.Cl |
| CAS DataBase Reference | 6276-54-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37-36-37/39 |
| WGK Germany | 3 |
| HS Code | 29211980 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | off-white to yellow-beige crystalline |
| Uses | 3-Chloropropylamine hydrochloride was used in chemical treatment of carbon-enriched fly ash concentrates. It was used in the synthesis of linear, star and comb-like polyacrylamides by atomic transfer radical polymerization. It was used in the synthesis of halogen-functionalized aliphatic polyketones (macroinitiators). |
| Synthesis | 156-87-6 6276-54-6 General procedure for the synthesis of 3-chloropropylamine hydrochloride from 3-amino-1-propanol: An anhydrous chloroform (30 mL) solution of thionyl chloride (8.68 g, 1.32 mmol) was slowly added dropwise to 3-amino-1-propanol (4.49 g, 59.19 mmol) at 0-10°C. The reaction mixture was heated to room temperature and refluxed for 3 hours. The reaction mixture was gradually warmed to room temperature and then heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration to afford the target product 3-chloropropylamine hydrochloride (7.07 g, 55.15 mmol, 93% yield) as a green solid. Electrospray mass spectrometry (ESMS) showed m/z 94 ([M+H]+). |
| References | [1] Patent: WO2014/18571, 2014, A2. Location in patent: Paragraph 00463 [2] Patent: WO2014/18570, 2014, A1. Location in patent: Paragraph 00261 [3] Angewandte Chemie - International Edition, 2018, vol. 57, # 19, p. 5413 - 5417 [4] Angew. Chem., 2018, vol. 130, p. 5511 - 5515,5 |
3-Chloropropylamine hydrochloride Preparation Products And Raw materials
| Raw materials | 3-Aminopropanol-->Thionyl chloride-->Chloroform |
| Preparation Products | 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE-->N-(3-Aminopropyl)morpholine-->3-chloropropylamine-->S-(3-aminopropyl)thiosulfuric acid ester-->Acetamide, N-(3-chloropropyl)-2,2,2-trifluoro--->(3-Chloropropyl)sulfaMoyl Chloride-->3-Aminopropyldimethylphosphine |
