3-IODO-4-METHOXYANILINE CAS 74587-12-5
3-IODO-4-METHOXYANILINE Basic information
| Product Name: | 3-IODO-4-METHOXYANILINE |
| Synonyms: | 3-IODO-4-METHOXYANILINE;3-Iodo-4-methoxy-phenylamine;3-Iodo-4-methoxyaniline,98%;4-Amino-2-iodoanisole;3-Iodo-p-anisidine;4-Amino-2-iodoanisole, 3-Iodo-p-anisidine;3-Iodo-4-methoxybenzenamine;4-AMino-2-iodoanisole[3-Iodo-4-Methoxyaniline] |
| CAS: | 74587-12-5 |
| MF: | C7H8INO |
| MW: | 249.05 |
| EINECS: | |
| Product Categories: | Iodine Compounds;Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates |
| Mol File: | 74587-12-5.mol |
3-IODO-4-METHOXYANILINE Chemical Properties
| Melting point | 74 °C |
| Boiling point | 321℃ |
| density | 1.807 |
| Fp | 148℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | soluble in Methanol |
| pka | 4.24±0.10(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
| InChIKey | UHPNLGCUIGEZRB-UHFFFAOYSA-N |
| CAS DataBase Reference | 74587-12-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2922290090 |
| Synthesis | 5399-03-1 74587-12-5 General procedure for the synthesis of 3-iodo-4-methoxyaniline from 2-iodo-4-nitroanisole: To a 250 mL round-bottomed flask were added 2-iodo-1-methoxy-4-nitrobenzene (6 g, 21.50 mmol, 1.00 eq.), iron powder (3.61 g, 64.50 mmol, 3.00 eq.), ammonium chloride (3.42 g, 63.94 mmol , 3.00 equiv), ethanol (50 mL) and water (10 mL). The reaction mixture was stirred at 85 °C for 1 hour. Upon completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The brown solid product 3-iodo-4-methoxyaniline (5.35 g, 100% yield) was obtained. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS): (electrospray ionization, m/z) retention time (RT) = 0.847 min, LCMS 53: m/z = 250 [M + 1]. |
| References | [1] Patent: WO2018/118842, 2018, A1. Location in patent: Paragraph 0421-0424 [2] Patent: WO2016/199943, 2016, A1. Location in patent: Paragraph 0303 [3] Patent: WO2013/14039, 2013, A1. Location in patent: Page/Page column 45-46 [4] Patent: WO2014/152029, 2014, A2. Location in patent: Paragraph 00230 [5] Journal of the American Chemical Society, 1941, vol. 63, p. 2482,2484 |
3-IODO-4-METHOXYANILINE Preparation Products And Raw materials
| Raw materials | 2-Iodoanisole-->2-Iodo-4-nitroanisole-->Water-->4-Nitroanisole-->o-Anisidine-->p-Anisidine-->Ethanol-->Iodine-->Iron-->Ammonium chloride |
