3-Nitrophenylhydrazine hydrochloride CAS 636-95-3
3-Nitrophenylhydrazine hydrochloride Basic information
| Product Name: | 3-Nitrophenylhydrazine hydrochloride |
| Synonyms: | 3-Nitrophenylhydrazine Hydrochloride, 97+%;3-NITROPHENYLHYDRAZINE HYDROCHLORIDE;3-nitrophenylhydrazinium(1+) chloride;3-NITROPHENYLHYDRAZINE HYDROCHLORIDE, 98 %;3-NitrophenylhydrazineHcl;3-Nitrophenylhydrazine Hcl 98%;3-Nitrophenylhydrazine hydrochloride, 98% 5GR;3-NITROPHENYLHYDRAZINE HYDROCHLORIDE 98% |
| CAS: | 636-95-3 |
| MF: | C6H8ClN3O2 |
| MW: | 189.6 |
| EINECS: | 211-270-6 |
| Product Categories: | Hydrazines;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 636-95-3.mol |
3-Nitrophenylhydrazine hydrochloride Chemical Properties
| Melting point | 210 °C (dec.)(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol (Slightly) |
| form | Solid |
| color | Yellow to Dark Yellow |
| BRN | 3569013 |
| InChI | 1S/C6H7N3O2.ClH/c7-8-5-2-1-3-6(4-5)9(10)11;/h1-4,8H,7H2;1H |
| InChIKey | BKOYKMLGFFASBG-UHFFFAOYSA-N |
| SMILES | Cl.NNc1cccc(c1)[N+]([O-])=O |
| CAS DataBase Reference | 636-95-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-37/39-36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 2928009090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | YELLOW CRYSTALLINE POWDER |
| Uses | 3-Nitrophenylhydrazine Hydrochloride acts as a reagent in the preparation of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents, preparation of pyrazolobenzothiazines as inhibitors of hepatitis C virus replication. |
| Synthesis | 99-09-2 51516-96-2 Example 28: Synthesis of 3-methyl-1H-indol-6-amine1. 3-Nitroaniline (27.6 g, 0.2 mol) was dissolved in a mixed solution of water (40 mL) and 37% hydrochloric acid (40 mL).2. A solution of sodium nitrite (NaNO2, 13.8 g, 0.2 mol) in water (60 mL) was slowly added to the above solution at 0 °C.3. Subsequently, a 37% hydrochloric acid (100 mL) solution of tin chloride dihydrate (SnCl2-2H2O, 135.5 g, 0.6 mol) was added, maintaining the reaction temperature at 0 °C.4. After continuous stirring of the reaction mixture at 0 °C for 0.5 h, the insoluble solid was separated by filtration and washed with cold water to afford (3-nitrophenyl)hydrazine hydrochloride (27.6 g, 73% yield).Example 49: Synthesis of 6-amino-1H-indole-2-carbonitrile1. 3-Nitroaniline (28 g, 0.20 mol) was dissolved in a mixture of water (40 mL) and 37% hydrochloric acid (40 mL).2. A solution of sodium nitrite (NaNO2, 14 g, 0.20 mol) in water (60 mL) was slowly added to the above solution at 0 °C.3. Subsequently, a 37% hydrochloric acid (100 mL) solution of tin chloride dihydrate (SnCl2-2H2O, 140 g, 0.60 mol) was added, maintaining the reaction temperature at 0 °C.4. After continuous stirring of the reaction mixture at 0 °C for 0.5 h, the insoluble solid was separated by filtration and washed with cold water to afford (3-nitrophenyl)hydrazine hydrochloride (28 g, 73% yield). |
| References | [1] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 110-111; 138 [2] Patent: US2012/309758, 2012, A1. Location in patent: Page/Page column 67 [3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0397; 1632; 1744 [4] Organic Preparations and Procedures International, 1991, vol. 23, # 3, p. 357 - 364 [5] Journal of Agricultural and Food Chemistry, 2014, vol. 62, # 2, p. 381 - 390 |
3-Nitrophenylhydrazine hydrochloride Preparation Products And Raw materials
| Raw materials | 3-Nitroaniline-->Sodium nitrite-->Hydrochloric acid-->Stannous chloride |
