4-Amino-3-hydrazino-1,2,4-triazol-5-thiol CAS 1750-12-5
4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Basic information
| Product Name: | 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol |
| Synonyms: | (4-Amino-5-mercapto-4H-1,2,4-triazole-3-yl)hydrazine;3-Hydrazino-4-amino-5-mercapto-4H-1,2,4-triazole;AKOS B029009;4-AMINO-5-HYDRAZINO-4H-1,2,4-TRIAZOLE-3-THIOL;4-Amino-3-hydrazino-1,2,4-triazol-5-thiol;4-AMINO-3-HYDRAZINO-5-MERCAPTO-1,2,4-TRIAZOLE;Purpald,4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole, 4-Amino-5-hydrazino-1,2,4-triazole-3-thiol;4-Amino-3-hydrazino- |
| CAS: | 1750-12-5 |
| MF: | C2H6N6S |
| MW: | 146.17 |
| EINECS: | 217-135-8 |
| Product Categories: | Heterocycles;Sulfur & Selenium Compounds;Aldehyde Labeling Reagents |
| Mol File: | 1750-12-5.mol |
4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Chemical Properties
| Melting point | 228-230 °C (dec.)(lit.) |
| Boiling point | 275.0±23.0 °C(Predicted) |
| density | 2.31±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | Soluble in Dimethyl sulfoxide. (DMSO) |
| pka | 8.52±0.20(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 134867 |
| Stability: | Light Sensitive |
| InChI | InChI=1S/C2H6N6S/c3-5-1-6-7-2(9)8(1)4/h3-4H2,(H,5,6)(H,7,9) |
| InChIKey | RDIMQHBOTMWMJA-UHFFFAOYSA-N |
| SMILES | N1=C(NN)N(N)C(=S)N1 |
| CAS DataBase Reference | 1750-12-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2,4-Triazolidin-3-one, 4-amino-5-thioxo-, hydrazone (1750-12-5) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 1325 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | 4.1 |
| PackingGroup | III |
| HS Code | 29339900 |
| Storage Class | 4.1A - Other explosive hazardous materials |
| Hazard Classifications | Flam. Sol. 1 |
| Chemical Properties | Beige solid |
| Uses | A reagent for the determination of aldehydes and other reactive chemicals |
| Uses | 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole is a reagent used in the determination of aldehydes and other reactive chemicals.was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid. It was used as chromogen during the determination of catalase activity in small tissue samples. It was used as reagent in determination of formaldehyde. It was used for derivatization of neutral monosaccharides during HPLC. |
| Uses |
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| Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 26, p. 355, 1989 DOI: 10.1002/jhet.5570260216 |
| Synthesis | 17356-08-0 1750-12-5 Thiourea (0.5 mol, 38 g) and 98% hydrazine hydrate (100 mL) were used as raw materials and the mixture was refluxed in a water bath for 3 hours. After completion of the reaction, the reaction mixture was cooled and diluted with 150 mL of distilled water. Subsequently, 10 mL of 2M HCl was added to neutralize to pH about 6.5 and frozen at 0 °C for 30 min. The crude product was obtained by filtration, washed with cold water and dissolved in 375 mL of 2M HCl and digested for 15 minutes. After removal of acid-insoluble impurities, the filtrate was neutralized to pH about 6.5 with NaOH and again frozen at 0°C. The solid product was gradually precipitated, filtered, washed several times with water, dried and recrystallized from water to give 4-amino-5-hydrazino-4H-[1,2,4]-triazole-3-thiol (1) as a white solid (24 g, 65% yield); melting point 244-246 °C (literature values 231-233 °C); FTIR (cm-1) 3439, 3262, 3185, 3076, 3014, 2915, 1638; 1H NMR (400 MHz, DMSO-d6) δ 12.70 (s, 1H, SH), 7.15 (s, 1H, NH), 5.28 (s, 2H, NH2), 4.15 (s, 2H, NH2-hydrazinyl); 13C NMR (100 MHz, DMSO-d6) δ 164.9, 155.1; Elemental analysis calculated values (C2H6N6S, 146): C, 16.43; H, 4.14; N, 57.49. Measured values: C, 16.48; H, 4.01; N, 57.36. |
| Purification Methods | Recrystallise Purpald from H2O (0.6g in 300-400mL). The benzylidene derivative has m 245-246o(dec) from i-PrOH [Hoggarth J Chem Soc 4817 1952, Dickinson & Jacobson J Chem Soc, Perkin Trans I 975 1975.[Beilstein 26 III/IV 547.] |
| References | [1] Synlett, 2016, vol. 27, # 11, p. 1703 - 1706 [2] Journal of the Indian Chemical Society, 1992, vol. 69, # 9, p. 577 - 578 [3] Synthetic Communications, 2017, vol. 47, # 11, p. 1102 - 1109 |
4-Amino-3-hydrazino-1,2,4-triazol-5-thiol Preparation Products And Raw materials
| Raw materials | Thionyl chloride-->Iodomethane-->Piperazine-->3-Piperidinemethanol-->1-Methyl-3-piperidinemethanol-->Carbamimidothioic acid |
