4-Hydrazinobenzoic acid hydrochloride CAS 24589-77-3

Introduction：Basic information about 4-Hydrazinobenzoic acid hydrochloride CAS 24589-77-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-Hydrazinobenzoic acid hydrochloride Basic information

• Product Name: 4-Hydrazinobenzoic acid hydrochloride
• Synonyms: LABOTEST-BB LT01596126;BIO-FARMA BF001082;P-CARBOXYPHENYL HYDRAZINE HCL;P HYDRAZINOBENZOIC ACID HYDROCHLORIDE;4-CARBOXYPHENYLHYDRAZINE HYDROCHLORIDE;4-HYDRAZINOBENZOIC ACID HCL;4-HYDRAZINOBENZOIC ACID HYDROCHLORIDE;4-hydrazino-benzoicacimonohydrochloride
• CAS: 24589-77-3
• MF: C7H9ClN2O2
• MW: 188.61
• EINECS: 246-330-0
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Phenylhydrazine;API intermediates;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 24589-77-3.mol

4-Hydrazinobenzoic acid hydrochloride Chemical Properties

• Melting point: 253 °C (dec.)(lit.)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Sparingly)
• form: Solid
• color: White to Off-White
• Water Solubility: Soluble in water.
• InChI: InChI=1S/C7H8N2O2.ClH/c8-9-6-3-1-5(2-4-6)7(10)11;/h1-4,9H,8H2,(H,10,11);1H
• InChIKey: XHLQMKQBCHYRLC-UHFFFAOYSA-N
• SMILES: C1(C(=O)O)=CC=C(NN)C=C1.Cl
• CAS DataBase Reference: 24589-77-3(CAS DataBase Reference)
• EPA Substance Registry System: Benzoic acid, 4-hydrazino-, monohydrochloride (24589-77-3)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DH1700000
• TSCA: TSCA listed
• HS Code: 2928009090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

4-Hydrazinobenzoic acid hydrochloride Usage And Synthesis

Chemical Properties

white to light yellow crystal powder     

Uses

4-Hydrazinobenzoic acid hydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. It may be used for the preparation of 4-(3-(2-(tert-butoxycarbonylamino)ethyl)-5-hydroxy-1H-pyrazol-1-yl)benzoic acid.

General Description

4-Hydrazinobenzoic acid (p-Hydrazinobenzoic acid, HBA) has been reported as an ingredient of the cultivated mushroom Agaricus bisporus. It is carcinogenic to rodents. Mechanism of DNA damage by 4-hydrazinobenzoic acid has been studied by using ³²P-labeled DNA fragments obtained from the human p53 and p16 tumor suppressor genes. It may be used for the preparation of 4-(3-(2-(tert-butoxycarbonylamino)ethyl)-5-hydroxy-1H-pyrazol-1-yl)benzoic acid.

Synthesis

To 600 ml beaker add water 150 ml, stirring, add p-aminobenzoic acid 27.4 g, 10N hydrochloric acid 57.5 ml, after cooling the solution to 0 ??, slowly add sodium nitrite solution (from 15 grams of sodium nitrite and 30 ml of water to formulate), add the end of the system, adjust the system pH for 1-2, control the temperature of the reaction system 5 ??, the reaction for 20 minutes, filtration and retention of the filtrate. Add 200 ml of water to a 1000 ml beaker, add 64 g of sodium metabisulfite and 78 g of sodium hydroxide with stirring, at this time, the solution pH was 7, the solution temperature was 35 ?? C. After the solution was cooled down to 15-18 ?? C, the above filtrate was added slowly, and the temperature of the solution was 20 ?? C when it was added, the pH was 7, and the reaction was carried out for 30 minutes, and then the temperature was raised to 50-60 ?? C, and 115 ml of hydrochloric acid was added to it, and the temperature continued to be raised to 97-100 ?? C, and the reaction was continued to be carried out for 20 minutes. Elevate the temperature to 97-100 ?? C, and at this temperature reaction for 30 minutes after adding 7 grams of activated carbon, decolorization after 90 ?? C filtration to retain the filtrate, cooled to 15 ?? C, add hydrochloric acid, the material precipitation, filtration, pumping dry to get the 4-carboxyphenylhydrazine hydrochloride product. The purity of 4-carboxyphenylhydrazine hydrochloride was 98.92% as measured by high performance liquid chromatography.