4-IODOTHIOANISOLE CAS 35371-03-0
Introduction：Basic information about 4-IODOTHIOANISOLE CAS 35371-03-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-IODOTHIOANISOLE Basic information
| Product Name: | 4-IODOTHIOANISOLE |
| Synonyms: | 4-Iodothiaanisole;(4-iodophenyl)(methyl)sulfane;1-(Methylthio)-4-iodobenzene;1-Iodo-4-(methylthio)benzene;Methyl p-iodophenyl sulfide;Methyl(4-iodophenyl) sulfide;p-Iodothioanisole;4-IODOTHIOANISOLE |
| CAS: | 35371-03-0 |
| MF: | C7H7IS |
| MW: | 250.1 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 35371-03-0.mol |
4-IODOTHIOANISOLE Chemical Properties
| Melting point | 40 °C |
| Boiling point | 262.6±23.0 °C(Predicted) |
| density | 1.78±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| Appearance | Light brown to brown Solid |
| CAS DataBase Reference | 35371-03-0(CAS DataBase Reference) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 29309090 |
| Chemical Properties | In solution, 4-Iodothioanisole shows a yellowish color due to intramolecular excitation of the cyclopentene system, while in the solid state it is orange because of free rotation around the carbon-iodine bond.It reacts with electrophiles to form carbon-iodine bonds and can be used to make cross-coupling reactions. |
| Uses | 4-Iodothioanisole is a synthetic molecule that is used in organic chemistry as a reagent for the formation of carbon-carbon bonds. It also enhances the fluorescence of some molecules and has been used in supramolecular chemistry. |
| Synthesis | 98546-51-1 35371-03-0 General procedure for the synthesis of 4-iodoanisole from 4-methylthiophenylboronic acid: KX (X = I, Br) (0.2 mmol), 4-methylthiophenylboronic acid (0.3 mmol), CuBr2 (4.5 mg, 10 mol%), 1,10-phenanthroline (7.2 mg, 20 mol%), and DMF ( 2 mL). The reaction mixture was stirred at 80 °C or 130 °C for the reaction. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified by rapid column chromatography on silica gel to afford the target product 4-iodoanisole. |
| References | [1] Tetrahedron Letters, 2011, vol. 52, # 16, p. 1993 - 1995 [2] Tetrahedron Letters, 2015, vol. 56, # 9, p. 1122 - 1123 [3] RSC Advances, 2015, vol. 5, # 103, p. 84910 - 84919 |
4-IODOTHIOANISOLE Preparation Products And Raw materials
| Raw materials | Dimethyl disulfide-->4-(Methylthio)phenylboronic acid-->4-Iodophenylboronic acid-->Cupric bromide-->N,N-Dimethylformamide-->o-Phenanthroline-->Potassium iodide-->Oxygen |
| Preparation Products | 4-(METHYLTHIO)BENZOYL CHLORIDE 95 |
