4-Methoxyphenylhydrazine hydrochloride CAS 19501-58-7
Introduction：Basic information about 4-Methoxyphenylhydrazine hydrochloride CAS 19501-58-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Methoxyphenylhydrazine hydrochloride Basic information
| Product Name: | 4-Methoxyphenylhydrazine hydrochloride |
| Synonyms: | 4-METHOXYPHENYLHYDRAZINIUM CHLORIDE FOR;IndoMethacin iMpurity (4-Methoxyphenylhydrazine hydrochloride);Hydrazine,(4-Methoxyphenyl)-, hydrochloride (1:1);(4-methoxyphenyl)hydrazine dihydrochloride;4-Methoxyphenylhydrazinium chloride for synthesis;[(4-methoxyphenyl)amino]ammonium chloride;[(4-methoxyphenyl)amino]azanium chloride;p-anisidinoammonium chloride |
| CAS: | 19501-58-7 |
| MF: | C7H11ClN2O |
| MW: | 174.63 |
| EINECS: | 243-115-3 |
| Product Categories: | Phenylhydrazine;Hydrazines;Amines and Anilines;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 19501-58-7.mol |
4-Methoxyphenylhydrazine hydrochloride Chemical Properties
| Melting point | 160-162 °C (dec.)(lit.) |
| storage temp. | Keep Cold |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder, Crystals and/or Chunks |
| color | Slightly pink to gray to purple |
| Water Solubility | soluble |
| BRN | 3566583 |
| Stability: | Light Sensitive |
| InChI | InChI=1S/C7H10N2O.ClH/c1-10-7-4-2-6(9-8)3-5-7;/h2-5,9H,8H2,1H3;1H |
| InChIKey | FQHCPFMTXFJZJS-UHFFFAOYSA-N |
| SMILES | C1(NN)=CC=C(OC)C=C1.Cl |
| CAS DataBase Reference | 19501-58-7(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 36/37-36-26 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| Hazard Note | Irritant/Harmful |
| HazardClass | IRRITANT, KEEP COLD |
| PackingGroup | III |
| HS Code | 29280090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Skin Sens. 1 |
| Description | 4-Methoxyphenylhydrazine hydrochloride is a kind of midbody that is mainly used for producing phenylhydrazine, and can also be used to make other Chemicals. The reparation technology of 4-Methoxyphenylhydrazine hydrochloride comprises aniline diazonium and benzene diazonium chloride diazo benzene chloride two-step process. |
| Chemical Properties | slightly pink to greyish-purple powder |
| Uses | 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. |
| Synthesis | 4-Methoxyphenylhydrazine hydrochloride Preparation Process: Take hydrochloric acid and sodium nitrite and add them sequentially to aniline, where the molar ratio of aniline to hydrochloric acid to sodium nitrite is 1:2.3 to 3.2:1 to 1.1, and sodium nitrite is added at 0 to 5°C. The reaction temperature is 0 to 22°C, and the reaction time is 30 to 90 minutes. Then add ammonium sulfite and hydrochloric acid according to a molar ratio to aniline of 1:2 to 3.5:2.5 to 3.0. After reduction, hydrolysis, and acidification, the product can be obtained by filtration or centrifugation. |
| References | [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3322 - 3336 [2] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 1, p. 1 - 11 [3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424 [4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696 [5] Journal of Organic Chemistry, 2011, vol. 76, # 13, p. 5295 - 5308 |
4-Methoxyphenylhydrazine hydrochloride Preparation Products And Raw materials
| Raw materials | p-Anisidine-->Hydrochloric acid-->Sodium nitrite-->Stannous chloride |
| Preparation Products | 1-(4-METHOXYPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE-->2,3,4,9-tetrahydro-6-methoxy-1H-pyrido[3,4-b]indol-1-one-->5-METHOXY-2-METHYLINDOLE-->2,3,3-Trimethyl-5-methoxy-3H-indole-->6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE-->Tepoxalin-->Acemetacin-->2H-Imidazole-2-thione, 1,3-dihydro-1-[(4-methoxyphenyl)amino]-4-methyl-5-phenyl--->ETHYL 1-(4-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER |
