4-Morpholinecarbonyl chloride CAS 15159-40-7

Introduction：Basic information about 4-Morpholinecarbonyl chloride CAS 15159-40-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4-Morpholinecarbonyl chloride Basic information

• Product Name: 4-Morpholinecarbonyl chloride
• Synonyms: 4-ChlorocarbonylmorpholineMorpholinocarbonyl Chloride;4-Morpholinecarbonyl;MORPHOLINE-4-CARBONYL CHLORIDE;MORPHOLIN-4-YLCARBONYL CHLORIDE;MORPHOLINOCARBONYL CHLORIDE;4-MORPHOLINE CARBONIC ACID CHLORIDE;4-MORPHOLINECARBONYL CHLORIDE;4-MORPHOLINYLCARBONYL CHLORIDE
• CAS: 15159-40-7
• MF: C5H8ClNO2
• MW: 149.58
• EINECS: 239-213-0
• Product Categories: Phosgene Derivatives;Building Blocks;Heterocyclic Building Blocks;Morpholines;Building Blocks;Chemical Synthesis;ACIDHALIDE;Heterocyclic Building Blocks;Morpholines/Thiomorpholines
• Mol File: 15159-40-7.mol

4-Morpholinecarbonyl chloride Chemical Properties

• Boiling point: 137-138 °C/33 mmHg (lit.)
• density: 1.282 g/mL at 25 °C (lit.)
• refractive index: n20/D 1.498(lit.)
• Fp: >230 °F
• storage temp.: Inert atmosphere,2-8°C
• pka: -2.16±0.20(Predicted)
• form: clear liquid
• color: Colorless to Light yellow
• BRN: 116257
• InChI: InChI=1S/C5H8ClNO2/c6-5(8)7-1-3-9-4-2-7/h1-4H2
• InChIKey: XMWFMEYDRNJSOO-UHFFFAOYSA-N
• SMILES: C(Cl)(N1CCOCC1)=O
• CAS DataBase Reference: 15159-40-7(CAS DataBase Reference)
• EPA Substance Registry System: 4-Morpholinecarbonyl chloride (15159-40-7)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 14-36/38-40
• Safety Statements: 26-30-36-38
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• TSCA: TSCA listed
• HazardClass: 8
• PackingGroup: II
• HS Code: 29349990
• Storage Class: 10 - Combustible liquids
• Hazard Classifications: Carc. 2 Eye Irrit. 2 Skin Irrit. 2

4-Morpholinecarbonyl chloride Usage And Synthesis

Uses

Photographic intermediate

Uses

4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging. It may be used in the synthesis of:

• morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amide
• morpholine-4-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide
• 2-isopropyl-6-methylpyrimidin-4-yl morpholine-4-carboxylate

General Description

4-Morpholinecarbonyl chloride is a photographic intermediate. Rates of solvolysis of 4-morpholinecarbonyl chloride with N-alkyl group in aqueous binary solvents of acetone, ethanol, methanol, methanol-d, 2,2,2-trifluoroethanol, pure water and D₂O has been determined. Preparation of 4-morpholinecarbonyl chloride has been reported.

Synthesis

4-Morpholinecarbonyl chloride is prepared by reacting morpholine hydrochloride with phosgene in an inert liquid medium such as toluene and xylene, at 50W150°C, pref. 60W120°C. The morpholine hydrochloride is prepared by dissolving 1 part by weight of morpholine in ≥4 parts of an inert liquid medium and introducing a slightly excessive HCl into the solution under agitation.

4-Morpholinecarbonyl chloride Preparation Products And Raw materials

• Raw materials: 4-Morpholinecarboxylic acid-->DICHLORO(1,10-PHENANTHROLINE)PALLADIUM(II)-->Ethyl morpholinocarboxylate-->(2,2'-BIPYRIDINE)DICHLOROPALLADIUM(II)-->2-Amino-4-tert-butylphenol-->CHLOROCARBONYLSULFENYL CHLORIDE-->Potassium ethylxanthate-->Chlorine-->N-Chlorosuccinimide-->Triphosgene-->PHOSGENE
• Preparation Products: MORPHOLINE-4-SULFONYL CHLORIDE