4-Morpholineethanesulfonic acid CAS 4432-31-9
Introduction：Basic information about 4-Morpholineethanesulfonic acid CAS 4432-31-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Morpholineethanesulfonic acid Basic informationApplication
| Product Name: | 4-Morpholineethanesulfonic acid |
| Synonyms: | MES 2-Morpholinoethanesulfonic acid;MES(2-(n-Morpholino)-ethanesulfonic acid), Free Acid;BBS13;FLJ20345;MKS1;ANTI-ME1 antibody produced in mouse;HUMNDME;ME1 |
| CAS: | 4432-31-9 |
| MF: | C6H13NO4S |
| MW: | 195.24 |
| EINECS: | 224-632-3 |
| Product Categories: | buffer;Pharmaceutical Raw Materials;Biochemistry;Good's Buffers;Biotechnology Performance Certified (BPC) BuffersBiological Buffers;Buffer Convenience Packaging;Buffer SolutionsBiological Buffers;Buffers A to ZBiological Buffers;Good Buffers;BioUltraBiological Buffers;Buffer SolutionsProtein Structural Analysis;AlphabeticalMolecular Biology;Biological Buffers;BioUltra Buffers;Molecular Biology Reagents;Optimization Reagents;X-Ray Crystallography;4432-31-9 |
| Mol File: | 4432-31-9.mol |
4-Morpholineethanesulfonic acid Chemical Properties
| Melting point | >300 °C(lit.) |
| Boiling point | 102°C |
| density | 1.208 (estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.5 M at 20 °C, clear |
| pka | pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011 |
| form | Powder |
| color | White |
| PH | 2.5-4.0 (25℃ in neat) |
| PH Range | 5.5 - 6.7 |
| Water Solubility | 185.2g/L at 20℃ |
| λmax | λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 |
| Merck | 13,5929 |
| BRN | 6350956 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Major Application | clinical research diagnostic assay manufacturing life science and biopharma ( ) metabolomics ( ) |
| InChI | 1S/C6H13NO4S/c8-12(9,10)6-3-7-1-4-11-5-2-7/h1-6H2,(H,8,9,10) |
| InChIKey | SXGZJKUKBWWHRA-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCN1CCOCC1 |
| LogP | -2.2 at 20℃ |
| CAS DataBase Reference | 4432-31-9(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Morpholineethanesulfonic acid (4432-31-9) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-22 |
| WGK Germany | 1 |
| RTECS | QE9104530 |
| TSCA | TSCA listed |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Application | 4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection. |
| Chemical Properties | White/clear crystalline powder |
| Uses | Biological buffer. |
| Uses | MES solution has been used to activate microspheres. It has also been used as a component of activating solution to activate carboxyl groups of poly lactic-co-glycolic acid (PLGA). |
| Definition | ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate. |
| General Description | MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. |
| Flammability and Explosibility | Not classified |
| storage | Store at RT |
| Purification Methods | Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.] |
4-Morpholineethanesulfonic acid Preparation Products And Raw materials
| Raw materials | Sodium sulfite-->Sodium hypochlorite-->Sulfur trioxide-->LARD-->METHYL LAURATE-->Methyl palmitate |
| Preparation Products | 2-Morpholin-4-yl-ethanesulfonyl chloride |
