5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE CAS 20869-95-8
Introduction：Basic information about 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE CAS 20869-95-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Basic information
| Product Name: | 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE |
| Synonyms: | KAEMPFEROL-3,4'-DIMETHYL ETHER;ERMANIN;5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE;5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE;3,4'-DIMETHOXY-5,7-DIHYDROXYFLAVONE;5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one;3,4'-Dimethoxykaempferol;Kaempferol 3,4'-di-O-methyl ether |
| CAS: | 20869-95-8 |
| MF: | C17H14O6 |
| MW: | 314.29 |
| EINECS: | 244-093-8 |
| Product Categories: | Flavanols |
| Mol File: | 20869-95-8.mol |
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Chemical Properties
| Melting point | 234 °C |
| Boiling point | 552.0±50.0 °C(Predicted) |
| density | 1.46±0.1 g/cm3(Predicted) |
| solubility | DMF: 20 mg/ml DMSO: 15 mg/ml |
| pka | 6.32±0.40(Predicted) |
| LogP | 2.400 (est) |
Safety Information
| Uses | Ermanin is a useful research chemical used in HIV-1 integrase inhibition. Ermanin exhibits actioxidant properties against peroxyl and hydroxyl radicals. |
| Definition | ChEBI: 3,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an anti-inflammatory agent, an antimycobacterial drug, an apoptosis inducer, an antineoplastic agent and a plant metabolite. It is a dihydroxyflavone and a dimethoxyflavone. It is functionally related to a kaempferol. |
| IC 50 | iNOS; Bacterial; COX-2 |
| References | [1] QIONG DING . The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis[J]. Free Radical Biology and Medicine, 2021, 176: Pages 392-405. DOI: 10.1016/j.freeradbiomed.2021.09.017 [2] JOSÉ ANTONIO GUERRA. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum[J]. International immunopharmacology, 2006, 6 11: Pages 1723-1728. DOI: 10.1016/j.intimp.2006.08.012 [3] NADINE DE MEYER. 4’-Hydroxy-3-methoxyflavones with potent antipicornavirus activity[J]. Journal of Medicinal Chemistry, 1991, 34 2: 736-746. DOI: 10.1021/jm00106a039 |
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Preparation Products And Raw materials
| Preparation Products | 5-Hydroxy-2-(4-methoxyphenyl)-3,7,8-trimethoxy-4H-1-benzopyran-4-one |
