5-Bromo-3-fluoro-pyridine-2-carbonitrile CAS 886373-28-0

Introduction：Basic information about 5-Bromo-3-fluoro-pyridine-2-carbonitrile CAS 886373-28-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

5-Bromo-3-fluoro-pyridine-2-carbonitrile Basic information

• Product Name: 5-Bromo-3-fluoro-pyridine-2-carbonitrile
• Synonyms: 5-bromo-3-fluoropicolinonitrile;5--3-·ú-2-áà¤×;5-BroMo-2-cyano-3-fluorop...;5-BroMo-2-cyano-3-fluoropyridine;5-Bromo-2-cyano-3-fluoropyridine, 5-Bromo-3-fluoropicolinonitrile;5-BROMO-3-FLUORO-PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 5-bromo-3-fluoro-;5-BroMo-3-fluoro-2-pyridinecarbonitrile
• CAS: 886373-28-0
• MF: C6H2BrFN2
• MW: 201
• EINECS: 688-366-3
• Product Categories: Heterocyclic Building Blocks
• Mol File: Mol File

5-Bromo-3-fluoro-pyridine-2-carbonitrile Chemical Properties

• Melting point: 103-105℃
• Boiling point: 238.0±35.0℃ (760 Torr)
• density: 1.81±0.1 g/cm3 (20 ºC 760 Torr)
• Fp: 97.7±25.9℃
• storage temp.: -20°C
• pka: -5.10±0.20(Predicted)
• form: solid
• color: Yellow
• InChI: InChI=1S/C6H2BrFN2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H
• InChIKey: HMURQOFNWZWERT-UHFFFAOYSA-N
• SMILES: C1(C#N)=NC=C(Br)C=C1F

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22-38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 2933399990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

5-Bromo-3-fluoro-pyridine-2-carbonitrile Usage And Synthesis

Uses

5-Bromo-3-fluoro-2-pyridinecarboxylonite is an off-white to pale yellow solid, commonly used as an intermediate in organic synthesis.

Synthesis

5-Bromo-3-fluoro-2-pyridinecarbonitrile is an off-white to pale yellow solid, commonly used as an intermediate in organic synthesis, such as the synthesis of 5-bromo-3-methoxypyridine-2-carbonitrile

References

[1] Patent: US2012/165338, 2012, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/89601, 2012, A1. Location in patent: Page/Page column 54
[3] Patent: WO2012/66070, 2012, A1. Location in patent: Page/Page column 96-97
[4] Patent: WO2005/63690, 2005, A1. Location in patent: Page/Page column 29
[5] Patent: WO2009/36996, 2009, A2. Location in patent: Page/Page column 105

5-Bromo-3-fluoro-pyridine-2-carbonitrile Preparation Products And Raw materials

• Raw materials: 5-broMo-3-fluoropicolinaMide-->5-Bromo-3-nitropyridine-2-carbonitrile-->5-BROMO-3-HYDROXYPICOLINONITRILE-->Hydrochloric acid-->Sulfuric acid-->N,N-Dimethylformamide-->Tetrabutylammonium fluoride-->2,5-Dibromo-3-nitropyridine-->5-Bromo-3-nitro-2-pyridinol
• Preparation Products: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile-->Methyl 5-broMo-3-fluoropyridine-2-carboxylate-->1-(5-Bromo-3-fluoropyridin-2-yl)ethanone