Introduction：Basic information about 5'-DEOXYADENOSINE CAS 4754-39-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5'-DEOXYADENOSINE Basic informationDescription
| Product Name: | 5'-DEOXYADENOSINE |
| Synonyms: | 5’-deoxy-adenosin;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methyl-oxolane-3,4-diol;6-Amino-9-(5-deoxy-β-D-ribofuranosyl)-9H-purine;9-(5-Deoxy-β-D-ribofuranosyl)-9H-purine-6-amine;Adenosine, 5'-deoxy-;5′-dAdo;2'-Deoxycytidine Monohydrate(2'-dC ? H?O);5'-Deoxyadenosine methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase substrate |
| CAS: | 4754-39-6 |
| MF: | C10H13N5O3 |
| MW: | 251.24 |
| EINECS: | |
| Product Categories: | Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol File: | 4754-39-6.mol |
|
5'-DEOXYADENOSINE Chemical Properties
| Melting point | 210-212 °C |
| Boiling point | 595.0±60.0 °C(Predicted) |
| density | 1.93±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 15 mg/ml |
| form | A crystalline solid |
| pka | 13.29±0.70(Predicted) |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | hot water: 19.60-20.40mg/mL, clear, colorless |
| InChI | InChI=1S/C10H13N5O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| InChIKey | XGYIMTFOTBMPFP-KQYNXXCUSA-N |
| SMILES | C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O |
Safety Information
| WGK Germany | 3 |
| RTECS | AU7358650 |
| Storage Class | 11 - Combustible Solids |
5'-DEOXYADENOSINE Usage And Synthesis
| Description | 5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. |
| Uses | 5′-Deoxyadenosine has been used:
- as a standard in mass spectroscopy
- as an inhibitor for screening thymidine phosphorylase activity
- as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay
|
| Definition | ChEBI: A 5'-deoxyribonucleoside compound having adenosine as the nucleobase. |
| Biochem/physiol Actions | 5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes. |
| IC 50 | Human Endogenous Metabolite |
5'-DEOXYADENOSINE Preparation Products And Raw materials
| Raw materials | 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE |
| Preparation Products | 5-Deoxy-D-ribose |
