| Description | 6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease. |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/6-aminohexanoic_acid#section=Pharmacology-and-Biochemistry
https://en.wikipedia.org/wiki/Aminocaproic_acid |
| Chemical Properties | white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform. |
| Originator | Epsilon,Roche,W. Germany,1962 |
| Uses | 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system. |
| Uses | EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature. |
| Definition | ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. |
| Application | 6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.
6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect. |
| Preparation | 6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide. |
| Manufacturing Process | 5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspondto a water:lactam molecular ratio of 50:1. After cooling, the small quantity ofthe nonsoluble substance that is formed is filtered off, and the filtrate isevaporated as far as possible. The resulting concentrate is mixed with threetimes its volume of strong alcohol, thereby causing the desired product,epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. Afterseparating the crystalline product thus obtained, a further quantity of epsilonaminocaproicacid can be obtained from the mother liquid if desired. |
| Brand name | Amicar (Xanodyne). |
| Therapeutic Function | Antifibrinolytic |
| General Description | 6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity. |
| Biochem/physiol Actions | Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. |
| Mechanism of action | Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysinegroups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which isa structural analog of lysine that only differs in that it has one less amino group, acts as acompetitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts thehomeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanismactivity. Aminocaproic acid, which is not a procoagulant, such as those used during surgicalintervention and various pathological conditions, is accompanied by an elevation in fibrinolyticactivity of blood and tissue. It is used to stop bleeding. |
| Safety Profile | Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,. |
| Synthesis | Aminocaproic acid (24.4.1) is synthesized by hydrolyzing |? -caprolactamat high temperature. |
| Veterinary Drugs and Treatments | Aminocaproic acid has been used as a treatment to degenerativemyelopathy (seen primarily in German shepherds), but no controlledstudies documenting its efficacy were located. There is interestin evaluating aminocaproic acid for adjunctive treatment ofthrombocytopenia in dogs, but efficacy and safety for this purposeremains to be investigated. In humans, it is primarily used for treatinghyperfibrinolysis-induced hemorrhage. |
