Introduction：Basic information about 6-Chloropurine ribonucleoside CAS 2004-06-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
6-Chloropurine ribonucleoside Basic information
| Product Name: | 6-Chloropurine ribonucleoside |
| Synonyms: | 6-chloropurineribonucleoside;6-CLPR;6-CHLORO-9-(BETA-D-RIBOFURANOSYL)PURINE;6-CHLOROINOSINE;6-CHLOROPURINE-9-RIBOSIDE;6-CHLOROPURINE NUCLEOSIDE;6-chloro-9-ribofuranosyl-9H-purine;6-Chloropurine riboside, pure, 99+% |
| CAS: | 2004-06-0 |
| MF: | C10H11ClN4O4 |
| MW: | 286.67 |
| EINECS: | 217-904-8 |
| Product Categories: | chiral;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents |
| Mol File: | 2004-06-0.mol |
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6-Chloropurine ribonucleoside Chemical Properties
| Melting point | 158-162 °C (dec.)(lit.) |
| Boiling point | 614.8±65.0 °C(Predicted) |
| density | 1.7303 (rough estimate) |
| refractive index | -45 ° (C=0.8, H2O) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| form | Powder |
| pka | 13.06±0.70(Predicted) |
| color | Yellow to Green |
| Optical Rotation | Consistent with structure |
| CAS DataBase Reference | 2004-06-0(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| RTECS | UO7520800 |
| F | 10-23 |
| Hazard Note | Irritant |
| HS Code | 29389090 |
6-Chloropurine ribonucleoside Usage And Synthesis
| Chemical Properties | white to light yellow crystal powde |
| Uses | 6-CHLOROPURINE RIBOSIDE acts as a reactant in the synthesis of isozyme-specific enzyme inhibitors as well as in the preparation of dog coronary artery receptor agonists. |
| Purification Methods | Purify the riboside by suspending the dry solid (~12 g) in hot MeOH (130 mL) and then adding enough hot H2O (~560mL) to cause solution, filter and set aside at 5o overnight. The colourless crystals of the riboside are filtered off, washed with Me2CO, Et2O and dried at 60o/0.1mm. More material can be obtained by evaporating the filtrate to dryness and recrystallisation of the residue from MeOH/H2O (2:1) (15mL/g). It has max 264nm ( 9140) in H2O. [Robins Biochemical Preparations 10 145 1963, Baker et al. J Org Chem 22 954 1957.] |
6-Chloropurine ribonucleoside Preparation Products And Raw materials
| Raw materials | [3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate-->2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE-->TETRAACETYLRIBOFURANOSE-->1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE-->2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside-->2',3',5'-Tri-O-acetylinosine-->Uridine-->Inosine-->6-Chloropurine |
| Preparation Products | 2-(6-ethylaminopurin-9-yl)-5-(hydroxymethyl)oxol-->N6-CYCLOHEXYLADENOSINE-->S-(4-NITROBENZYL)-6-THIOINOSINE-->Adenosine, N-(6-aminohexyl)--->6-Chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside-->TECADENOSON-->6-CHLOROPURINE RIBOSIDE-5'-O-MONOPHOSPHATE SODIUM SALT |
