CAS 16321-99-6|2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

Introduction：Basic information about CAS 16321-99-6|2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
CAS Number16321-99-6Molecular Weight427.80
Density1.7g/cm3Boiling Point637ºC at 760mmHg
Molecular FormulaC16H18ClN5O7Melting Point146.0 to 150.0 °C
MSDS/Flash Point339ºC

Names

Name(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
SynonymMore Synonyms

BiologicalActivity

Description2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

Density1.7g/cm3
Boiling Point637ºC at 760mmHg
Melting Point146.0 to 150.0 °C
Molecular FormulaC16H18ClN5O7
Molecular Weight427.80
Flash Point339ºC
Exact Mass427.08900
PSA157.75000
LogP0.96700
Vapour Pressure4E-16mmHg at 25°C
Index of Refraction1.69
InChIKeyHLVGVJFVAKPFOZ-SDBHATRESA-N
SMILESCC(=O)OCC1OC(n2cnc3c(Cl)nc(N)nc32)C(OC(C)=O)C1OC(C)=O

Synonyms

2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
[(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate
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