Introduction：Basic information about 7,8-DIHYDRO-L-BIOPTERIN CAS 6779-87-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
7,8-DIHYDRO-L-BIOPTERIN Basic information
| Product Name: | 7,8-DIHYDRO-L-BIOPTERIN |
| Synonyms: | 7,8-dihydrobiopterin;7,8-DIHYDRO-L-BIOPTERIN;2-AMINO-6-(1R,2S-DIHYDROXYPROPYL)-7,8-DIHYDRO-4(1H)-PTERIDINONE;1-(2-Amino-4-hydroxy-7,8-dihydropteridin-7-yl)propane-1,2-diol;BH2;DIHYDROBIOPTERIN;2-Amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one;2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone |
| CAS: | 6779-87-9 |
| MF: | C9H13N5O3 |
| MW: | 239.23 |
| EINECS: | 229-641-6 |
| Product Categories: | Amines;Bases & Related Reagents;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;All Inhibitors;Inhibitors;Neurochemicals |
| Mol File: | 6779-87-9.mol |
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7,8-DIHYDRO-L-BIOPTERIN Chemical Properties
| Melting point | >300°C dec. |
| Boiling point | 470.8±55.0 °C(Predicted) |
| density | 1.88 |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 10.47±0.20(Predicted) |
| color | Pale Yellow to Brown |
| BRN | 536551 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,6-/m0/s1 |
| InChIKey | FEMXZDUTFRTWPE-AWFVSMACSA-N |
| SMILES | N1C2=C(N=C([C@@H](O)[C@@H](O)C)CN2)C(=O)NC=1N |
| CAS DataBase Reference | 6779-87-9 |
Safety Information
| WGK Germany | 3 |
| F | 3-10 |
| Storage Class | 11 - Combustible Solids |
7,8-DIHYDRO-L-BIOPTERIN Usage And Synthesis
| Description | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. |
| Chemical Properties | Yellow Powder |
| Uses | An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G |
| Uses | The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. |
| Uses | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. |
| Definition | ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin. |
| references | [1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700. |
7,8-DIHYDRO-L-BIOPTERIN Preparation Products And Raw materials
| Preparation Products | 2-AMINO-4-HYDROXY-PTERIDINE-6-CARBALDEHYDE |
