Introduction：Basic information about 7-Ethylindole CAS 22867-74-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
7-Ethylindole Basic information
| Product Name: | 7-Ethylindole |
| Synonyms: | TIMTEC-BB SBB007573;7-ETHYL-INDOL;7-ETHYLINDOLE(ETODOLAC INTERMEDIATE);7-Ethylindole,98+%;7-ETHYLCAMPTOTHECIN;7-ETHYLINDOLE;7-Ethylindole,97%;7-Ethylindole, 97% 25GR |
| CAS: | 22867-74-9 |
| MF: | C10H11N |
| MW: | 145.2 |
| EINECS: | 682-584-2 |
| Product Categories: | Indoles and derivatives;Indole;Building Blocks;Heterocyclic Building Blocks;Indoles |
| Mol File: | 22867-74-9.mol |
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7-Ethylindole Chemical Properties
| Melting point | 82.5°C (estimate) |
| Boiling point | 230 °C |
| density | 1.058 g/mL at 20 °C(lit.) |
| refractive index | n20/D 1.603 |
| Fp | 230°C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 17.30±0.30(Predicted) |
| form | Oil |
| Specific Gravity | 1.058 |
| color | Clear Colorless to Light Brown |
| Water Solubility | INSOLUBLE |
| BRN | 1238356 |
| InChI | InChI=1S/C10H11N/c1-2-8-4-3-5-9-6-7-11-10(8)9/h3-7,11H,2H2,1H3 |
| InChIKey | PIIZLMYXLGYWTN-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2CC)C=C1 |
| CAS DataBase Reference | 22867-74-9(CAS DataBase Reference) |
Safety Information
| Safety Statements | 23-24/25 |
| WGK Germany | 3 |
| HS Code | 29339980 |
7-Ethylindole Usage And Synthesis
| Chemical Properties | clear yellow to red-brown liquid |
| Uses | 7-Ethylindole is a useful intermediate for etodolac derivative synthesis. It is also used in preparation of benzoheterocycles using butoxy-dihydrofurans as [4+2] benzannulation reagents. |
| Application | 7-Ethylindole serves as a crucial intermediate for producing pharmaceutical agents. It represents a new addition to the liquid organic hydrogen carrier (LOHC) family, known as 7-ethylindole (7-EID). With a low melting point of -14 °C and a substantial hydrogen content of 5.23 wt%, it stands out among its counterparts. The hydrogenation process of this compound utilized a commercial 5 wt% Ru/Al2O3 catalyst under H2 pressure ranging from 5–8 MPa and temperatures ranging from 120–160 °C. It was observed that the hydrogenation rate correlates positively with the reaction temperature. However, the effect of H2 pressure on the rate was minimal if the pressure exceeded 6 MPa. Complete dehydrogenation of 8H-7-EID to 7-EID was achieved within 270 minutes at 190 °C. The liberated H2 exhibited high purity, meeting the requirements of proton exchange membrane fuel cells[1]. |
| References | [1] Zhiwen Chen. “7-ethylindole: A new efficient liquid organic hydrogen carrier with fast kinetics.” International Journal of Hydrogen Energy 43 28 (2018): Pages 12688-12696. |
7-Ethylindole Preparation Products And Raw materials
| Preparation Products | 1H-Indole-3-carboxylic acid, 7-ethyl- |
