Acethydrazide CAS 1068-57-1
Introduction：Basic information about Acethydrazide CAS 1068-57-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Acethydrazide Basic informationDescription
| Product Name: | Acethydrazide |
| Synonyms: | 374;Acetyl hydrazide;ACETIC ACID HYDRAZIDE;ACETOHYDRAZIDE;ACETIC HYDRAZIDE;ACETHYDRAZIDE;AKOS 90782;Acethydrazide=Acetylhydrazide |
| CAS: | 1068-57-1 |
| MF: | C2H6N2O |
| MW: | 74.08 |
| EINECS: | 213-948-7 |
| Product Categories: | Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;bc0001;1068-57-1 |
| Mol File: | 1068-57-1.mol |
Acethydrazide Chemical Properties
| Melting point | 58-68 °C (lit.) |
| Boiling point | 129 °C/18 mmHg (lit.) |
| density | 1.0968 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Moist Crystals and Chunks |
| pka | 13.46±0.18(Predicted) |
| color | White |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 506165 |
| InChI | 1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5) |
| InChIKey | OFLXLNCGODUUOT-UHFFFAOYSA-N |
| SMILES | CC(=O)NN |
| CAS DataBase Reference | 1068-57-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, hydrazide(1068-57-1) |
| EPA Substance Registry System | Acetic acid hydrazide (1068-57-1) |
Safety Information
| Hazard Codes | Xn,T |
| Risk Statements | 22-36/38-68-40-25 |
| Safety Statements | 26-36-45-36/37 |
| RIDADR | 1759 |
| WGK Germany | 1 |
| RTECS | AI1225000 |
| F | 3-8-10 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29280090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Carc. 2 Eye Irrit. 2 Muta. 2 Skin Irrit. 2 |
| Toxicity | LD50 oral in bird - wild: 42200ug/kg |
| Description | Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2]. |
| Chemical Properties | White moist crystals and chunks |
| Uses | Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine. Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand. |
| Definition | ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group. |
| Safety Profile | Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,. |
| Synthesis | A kind of preparation method of acethydrazide include the following steps: Under nitrogen protection, by acetic acid, hydrazine hydrateIt is put into catalyst in the reaction kettle with rectifying column, opens stirring, be heated to reflux, after steam enters rectifying column,Vapor are produced in tower top temperature for 98°C~100°C, when reaction 4~6 is small at a reflux temperature, when rectifying tower top frozen-free currentReaction terminates after going out, and continues heating distillation, and the acetic acid and hydrazine hydrate of reaction are had neither part nor lot in 100°C~120°C extraction of tower top temperature,After acetic acid and hydrazine hydrate are all steamed, liquid in kettle is poured out into filtering while hot, filtrate is through crystallisation by cooling, pure water, veryAcethydrazide finished product is obtained after sky is dry. |
| Purification Methods | Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.] |
| References | [1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28. [2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152. |
Acethydrazide Preparation Products And Raw materials
| Raw materials | 2-N-BUTOXYETHYL METHACRYLATE-->Acetamide,N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)--->NSC45006-->2-butanone (1-methylpropylidene)hydrazone-->Hydrazinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester (9CI)-->3,6-Dithia-1,8-octanediol-->Ethyl acetimidate hydrochloride-->Dibenzoylmethane-->Benzoylacetone-->Acetamide |
| Preparation Products | 2-Mercapto-5-methyl-1,3,4-thiadiazole-->5-Methyl-1,3,4-oxadiazol-2(3H)-one-->FlubroMazolaM-->2-Amino-5-methyl-1,3,4-thiadiazole-->Ethyl 5-Methyl-1,3,4-thiadiazole-2-carboxylate-->Methylamine nitrate-->5-METHYL-1,3,4-OXADIAZOL-2-YLAMINE-->(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
