Introduction：Basic information about Aloin CAS 1415-73-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Aloin Basic information
| Product Name: | Aloin |
| Synonyms: | barbaloin from aloe barbadensis*miller leaves;Barbaloin std.;BarbaloinStandard;9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-;1,8-dihydroxy-10-(β-d-glucopyranosyl)-3-(hydroxymethyl)-9(10h)-anthracenone;ALOIN A(BARBALOIN)(P);ALOIN A(BARBALOIN)(SH);ALOIN B(P)(NEW) |
| CAS: | 1415-73-2 |
| MF: | C21H22O9 |
| MW: | 418.39 |
| EINECS: | 215-808-0 |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Plant extract;Herb extract;Natural Plant Extract |
| Mol File: | 1415-73-2.mol |
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Aloin Chemical Properties
| Melting point | 148°C |
| Boiling point | 456.17°C (rough estimate) |
| density | 1.3028 (rough estimate) |
| refractive index | 1.6230 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | pyridine: 50 mg/mL, clear, dark red |
| form | Solid |
| pka | 7.12±0.40(Predicted) |
| color | Yellow needles from EtOH |
| biological source | Curacao aloe |
| BRN | 6077558 |
| Stability: | Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible. |
| Major Application | metabolomics
vitamins, nutraceuticals, and natural products |
| InChIKey | AFHJQYHRLPMKHU-WEZNYRQKSA-N |
| SMILES | [C@@]1([H])([C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO)O2)O)C2C=CC=C(O)C=2C(=O)C2=C(O)C=C(CO)C=C12 |&1:0,2,3,5,6,8,r| |
| LogP | 0.944 (est) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | LZ6520000 |
| F | 8 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LDLo orl-cat: 500 mg/kg HBAMAK 4,1298,35 |
Aloin Usage And Synthesis
| Chemical Properties | lemon yellow crystalline powder |
| Uses | Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Recent studies have investigated Aloin as an antineoplastic agent that enhances melanogenesis and transglutaminase activity. |
| Uses | Aloe exudant, used as a stimulant-laxative |
| Definition | ChEBI: A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S dastereoisomer). |
| Biological Activity | Purgative activity in rats requires activation by Eubacterium sp. strain BAR or similar intestinal anaerobe, presumably by conversion to aloe-emodin anthrone. |
| Safety Profile | Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits acrid smoke and fumes.A carthartic and purgative. |
| Purification Methods | Aloin forms the monohydrate as lemon yellow crystals on crystallisation from H2O (450g/1.5L) which has a lower m ~70-80o than the anhydrous substance. [Cahn & Simonsen J Chem Soc 2573 1932, Hay & Haynes J Chem Soc 3141 1956.] |
Aloin Preparation Products And Raw materials
| Raw materials | LIGNITE-->Sodium hydroxide |
