Introduction：Basic information about ALPHA-AMANITIN CAS 23109-05-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
ALPHA-AMANITIN Basic information
| Product Name: | ALPHA-AMANITIN |
| Synonyms: | Aids004473;Aids-004473;AMANITIN, a-(RG);AMANITIN, a-(RG)(CALL);cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide;alpha-AMantine, froM AManita Phalloides;AMANITIN, A-;ALPHA-AMANITIN |
| CAS: | 23109-05-9 |
| MF: | C39H54N10O14S |
| MW: | 918.98 |
| EINECS: | 245-432-2 |
| Product Categories: | Alkaloids;DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience;Gene Regulation and Expression;Cell Signaling and Neuroscience;Mushroom;Toxins and Venoms;Enzyme Inhibitors;Enzyme Inhibitors by Type;Other;Miscellaneous Enzyme;inhibitor |
| Mol File: | 23109-05-9.mol |
|
ALPHA-AMANITIN Chemical Properties
| Melting point | 254-255 °C(lit.) |
| alpha | D20 +191° |
| Boiling point | 1622.2±65.0 °C(Predicted) |
| density | 1.1626 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| storage temp. | −20°C |
| solubility | H2O: 1.0 mg/mL |
| form | powder |
| pka | 9.63±0.70(Predicted) |
| color | white to light yellow |
| biological source | Amanita phalloides |
| Optical Rotation | +19120 (H2O) |
| Water Solubility | Soluble to 5 mM in ethanol and to 5 mM in water |
| ε(extinction coefficient) | 13,500 at 310nm in H2O at 1M |
| Merck | 13,370 |
| BRN | 1071138 |
| InChIKey | CIORWBWIBBPXCG-PWKRRBCNNA-N |
| SMILES | CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2 |
Safety Information
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-33-26/28 |
| Safety Statements | 36/37/39-45-36/37-28 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | BD6195000 |
| F | 8-10-18-21 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 2934999090 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Oral
STOT RE 2 |
| Hazardous Substances Data | 23109-05-9(Hazardous Substances Data) |
| Toxicity | LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland) |
ALPHA-AMANITIN Usage And Synthesis
| Uses | α-Amanitin has been used:
- for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
- to induce nephrotoxicity in mice renal tissues
- to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay
|
| Biological Activity | α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure. |
| Biochem/physiol Actions | The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis. |
| in vivo | The intravenous LD50 dose of alpha-Amanitin is 0.327 mg/kg body weight after intravenous injection into BALB/c mice. After 12 h of alpha-Amanitin injection in caudal vein, the levels of WBC, RBC and HGB decrease significantly, while those of BUN and Crea increase significantly in serum. alpha-Amanitin inhibits some genes (Hsp90b1, Irx4, etc.), whose encoded proteins regulate the RNA polymerase II activity. alpha-Amanitin down-regulates some proteins (Nmi, Trpc5, etc.) taking part in the transcription progress[1]. alpha-Amanitin has potent activity in DTC suppression. Mice injected with alpha-Amanitin (0.4 mg/kg, i.p.)-treated cells maintain their body weight, while those receiving a peritoneal injection of MKN45 cells show a constant decrease in body weight[2]. |
| IC 50 | Traditional Cytotoxic Agents |
| storage | Store at -20°C |
ALPHA-AMANITIN Preparation Products And Raw materials
