ALPHA-HEDERIN CAS 27013-91-8

Introduction：Basic information about ALPHA-HEDERIN CAS 27013-91-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

ALPHA-HEDERIN Basic information

• Product Name: ALPHA-HEDERIN
• Synonyms: ALPHA-HEDERIN;HELIXIN;α-hederin 27013-91-8;alpha-Hederin (α-Hederin);kizutasaponink6;koronarosidea;nepalin2;olean-12-en-28-oicacid,3-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabi
• CAS: 27013-91-8
• MF: C41H66O12
• MW: 750.96
• EINECS: 248-166-5
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Tri-Terpenoids;Saponins
• Mol File: 27013-91-8.mol

ALPHA-HEDERIN Chemical Properties

• Melting point: 215°C (dec.)
• alpha: D20 +14.5° (c = 0.92 in methanol)
• Boiling point: 849.6±65.0 °C(Predicted)
• density: 1.32
• storage temp.: Sealed in dry,2-8°C
• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
• pka: 4.63±0.70(Predicted)
• form: powder
• color: White-beige
• Stability: Hygroscopic
• InChIKey: KBKXVOJBOOKRQW-OGHMGUQHSA-N
• LogP: 8.370 (est)

Safety Information

• Risk Statements: 22
• Safety Statements: 22-45-24/25
• RIDADR: 1544
• WGK Germany: 3
• RTECS: RK0177800
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

ALPHA-HEDERIN Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in water, methanol and ethanol, derived from euphorbia.

Uses

α-Hederin is a saponin of dry extracts from the leaves of Hedera helix L.Inhibitor of β2-adrenergic receptor-GFP fusion proteins. Potential cause for asphyxiation.

Definition

ChEBI: A triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. Ithas been isolated from the stem bark of Kalopanax pictus.

in vivo

alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses^[3].