Introduction：Basic information about AP1867 CAS 195514-23-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
AP1867 Basic information
| Product Name: | AP1867 |
| Synonyms: | AP1867;2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[3-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-;AP-1867,AP1867;2-(3-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid;dTAG acid;({3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]hexahydropyridin-2-yl]carbonyl}oxy)propyl]phenyl}oxy)acetic acid;(1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate |
| CAS: | 195514-23-9 |
| MF: | C38H47NO11 |
| MW: | 693.78 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 195514-23-9.mol |
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AP1867 Chemical Properties
| Boiling point | 814.2±65.0 °C(Predicted) |
| density | 1.214±0.06 g/cm3(Predicted) |
| storage temp. | -20°C, protect from light |
| solubility | DMSO : ≥ 125 mg/mL (180.17 mM);Water : < 0.1 mg/mL (insoluble) |
| pka | 3.14±0.10(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | XCCRAOPQCACRFC-OIFRRMEBSA-N |
| SMILES | N1(C(=O)[C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)CCCC[C@H]1C(O[C@@H](C1=CC=CC(OCC(O)=O)=C1)CCC1=CC=C(OC)C(OC)=C1)=O |
Safety Information
AP1867 Usage And Synthesis
| Uses | AP1867 is a synthetic FKBP12F36V-directed ligand[1]. |
| References | [1] Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441. DOI:10.1038/s41589-018-0021-8
[2] Koide K, et al. A synthetic library of cell-permeable molecules. J Am Chem Soc. 2001 Jan 24;123(3):398-408. DOI:10.1021/ja0023377 |
AP1867 Preparation Products And Raw materials
