Arctiin CAS 20362-31-6

Introduction：Basic information about Arctiin CAS 20362-31-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Arctiin Basic information

• Product Name: Arctiin
• Synonyms: ARCTIGENIN-O-BETA-D-GLUCOPYRANOSIDE;(-)-ARCTIIN;ARCTIIN;ARCTIIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]-3-[[4-(-D-GLUCOPYRANOSYLOXY)-3-METHOXYPHENYL]METHYL]DIHYDRO-, (3R,4R)-,;ARCTIIN(P);(-)-Arctin,Arctiumlappa;2 (3H)-Furanone, 4-[(3, 4-dimethoxyphenyl)methyl]-3-[[4-(.beta.-D-gluc opyranosyloxy)-3-met hoxyphenyl]methyl]dihydro-, (3R-trans)-;2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]-3-[[4-(-D-GLUCOPYRANOSYLOXY)-3-METHOXYPHENYL]METHYL]DIHYDRO-, (3R,4R)-
• CAS: 20362-31-6
• MF: C27H34O11
• MW: 534.55
• Product Categories: Miscellaneous Natural Products;Natural Plant Extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 20362-31-6.mol

Arctiin Chemical Properties

• Melting point: 107.0 to 111.0 °C
• Boiling point: 756.4±60.0 °C(Predicted)
• density: 1.363±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: White to off-white solid.
• pka: 12.83±0.70(Predicted)
• color: White to Off-White
• λmax: 278nm(EtOH)(lit.)
• Major Application: metabolomics vitamins, nutraceuticals, and natural products
• Cosmetics Ingredients Functions: ANTIOXIDANT
• InChIKey: XOJVHLIYNSOZOO-SWOBOCGESA-N
• SMILES: [C@@H]1(COC(=O)[C@@H]1CC1=CC=C(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO)O2)O)C(OC)=C1)CC1=CC=C(OC)C(OC)=C1 |&1:0,5,12,13,15,16,18,r|
• LogP: -0.564 (est)
• CAS DataBase Reference: 20362-31-6(CAS DataBase Reference)

Safety Information

• WGK Germany: 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

Arctiin Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, derived from Arctium lappa, Forsythia suspensa, and Trachelospermum chinense.

Uses

Arctiin is a phytochemical acting as a UV filter. It protects against UVB radiation exposure.

Definition

ChEBI: Arctiin is a glycoside and a lignan.

Biological Activity

Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer. Arctiin has also shown antiviral activity against influenza A when used alone or in combination with oseltamivir. Arctiin plays an important role in the process of inflammation, by preventing the release of nitric oxide, prostaglandin E2, TNF-α (tumor necrosis factor - α), interleukin (IL)-1β and IL-6. A study using r at model shows th at arctiin possess anti-diabetic activity and might serve as an inhibitor of diabetic retinopathy.', 'Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer. Arctiin has also shown antiviral activity against influenza A when used along or in combination with oseltamivir.

in vivo

Arctiin (120 mg/kg for p.o.;Once daily for 3 weeks) significantly improves cBSA-induced glomerulonephritis in glomerulonephritis rat model^[4].

• Animal Model: Glomerulonephritis rat model^[4]
• Dosage: 30, 60, and 120 mg/kg
• Administration: Oral gavage (p.o.);Once daily for 3 weeksv
• Result: Significantly decreased the levels of urine protein. Markedly ameliorated the renal function. Dramatically reduced IL-6 and TNF-a concentration in rat serum. Dramatically decreased the NF-kB DNA binding activity. Significantly reduced the MDA level and increased the SOD activity.