Atipamezole hydrochloride CAS 104075-48-1

Introduction：Basic information about Atipamezole hydrochloride CAS 104075-48-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Atipamezole hydrochloride Basic information

• Product Name: Atipamezole hydrochloride
• Synonyms: 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride;Atipamezole HCL;4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride;4-(2-Ethyl-2-indanyl)imidazole hydrochloride;Atipamezole hydrochloride;Antisedan;MPV 1248 hydrochloride;MPV1248 hydrochloride
• CAS: 104075-48-1
• MF: C14H16N2.HCl
• MW: 248.75
• EINECS: 105-700-9
• Product Categories: API
• Mol File: 104075-48-1.mol

Atipamezole hydrochloride Chemical Properties

• Melting point: 211-215°
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• Merck: 14,861
• InChI: InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
• InChIKey: PCCVCJAQMHDWJY-UHFFFAOYSA-N
• SMILES: C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl
• CAS DataBase Reference: 104075-48-1(CAS DataBase Reference)

Safety Information

• RTECS: NI6139000
• HS Code: 2933.29.2000
• Toxicity: LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin)

Atipamezole hydrochloride Usage And Synthesis

Uses

Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.

Biological Activity

Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.

Side effects

A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination, and defecation may occur. In very rare cases, recurrence of sedation may occur, or the recovery time may not be shortened after administration of atipamezole. In cats, when using low doses to reverse the effects of medetomidine or dexmedetomidine partially, the possibility of hypothermia (even when aroused from sedation) should be guarded against.

Veterinary Drugs and Treatments

Atipamezole is labeled for use as a reversal agent for medetomidineand dexmedetomidine. It potentiallycould be useful for reversalof other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine,clonidine, tizanidine, brimonidine).

storage

Desiccate at RT