Introduction：Basic information about Azosemide CAS 27589-33-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Azosemide Basic information
| Product Name: | Azosemide |
| Synonyms: | 2-chloro-5-(1h-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-benzenesulfonamid;2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenyl-sulfanilamid;SK-110;2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide;2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide;2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide;Azosemide Solution, 1000ppm;Azosemide Solution, 100ppm |
| CAS: | 27589-33-9 |
| MF: | C12H11ClN6O2S2 |
| MW: | 370.84 |
| EINECS: | 248-549-7 |
| Product Categories: | |
| Mol File: | 27589-33-9.mol |
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Azosemide Chemical Properties
| Melting point | 218-221° |
| Boiling point | 221°C (rough estimate) |
| density | 1.6843 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 3.58±0.10(Predicted) |
| color | Crystals |
| InChI | InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) |
| InChIKey | HMEDEBAJARCKCT-UHFFFAOYSA-N |
| SMILES | C1(S(N)(=O)=O)=CC(C2=NNN=N2)=C(NCC2SC=CC=2)C=C1Cl |
| CAS DataBase Reference | 27589-33-9(CAS DataBase Reference) |
Safety Information
| Toxicity | LD50 orl-rat: 2545 mg/kg IYKEDH 18,666,87 |
Azosemide Usage And Synthesis
| Description | Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions. |
| Chemical Properties | Crystallized, melting point 220-223℃. |
| Originator | Boehringer Manheim (W. Germany) |
| Uses | Diuretic. |
| Uses | Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension. |
| Definition | ChEBI: A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hyprtension. |
| Manufacturing Process | The 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrile used as starting materialis obtained by the reaction of 4-chloro-2-fluoro-5-sutfamoyl-benzonitrile withthenylamine in anhydrous tetrahydrofuran.
Then the 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole (MP 218°to 221°C, yield 37% of theory) is obtained by the reaction of 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrite (MP 170° to 174°C) with sodium azideand ammonium chloride, |
| Brand name | LURET |
| Therapeutic Function | Diuretic |
| Safety Profile | Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. An experimental teratogen. Whenheated to decomposition it emits toxic fumes of Cl-, SOx,and NOx. |
Azosemide Preparation Products And Raw materials
| Raw materials | Sodium azide-->Benzonitrile |
