Bambuterol hydrochloride CAS 81732-46-9

Introduction：Basic information about Bambuterol hydrochloride CAS 81732-46-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Bambuterol hydrochloride Basic information

• Product Name: Bambuterol hydrochloride
• Synonyms: KWD-2183;BAMBUTEROL HCL;BAMBUTEROL HYDROCHLORIDE;BAMBEC;Bambuterol monohydrochloride;dimethylcarbamic acid 5-[2[(1,1-dimethyl)amino]1-hydroxyethyl]-1,3-phenylene ester hydrochloride;DIMETHYLCARBAMIC ACID 5-[2-[(1,1-DIMETHYLETHYL)AMINO]-1-HYDROXYETHYL]-1,3-PHENYLENE ESTER HYDROCHLORIDE;Bambuterol hydrochloride, 98%, a long acting beta-adrenoceptor agonist (LABA)
• CAS: 81732-46-9
• MF: C18H30ClN3O5
• MW: 403.9
• EINECS: 643-060-9
• Product Categories: BAMBEC;Bambuterol;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients
• Mol File: 81732-46-9.mol

Bambuterol hydrochloride Chemical Properties

• Melting point: 222-224°C
• storage temp.: Inert atmosphere,Room Temperature
• solubility: H₂O: ~33 mg/mL, soluble
• form: powder
• color: off-white
• Merck: 14,953
• Major Application: pharmaceutical (small molecule)
• InChI: 1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H
• InChIKey: LBARATORRVNNQM-UHFFFAOYSA-N
• SMILES: Cl.CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C
• CAS DataBase Reference: 81732-46-9(CAS DataBase Reference)

Safety Information

• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29242990
• Storage Class: 11 - Combustible Solids

Bambuterol hydrochloride Usage And Synthesis

Description

Bambuterol is an inactive prodrug of terbutaline. It has a prolonged durationof action when administered orally.

Chemical Properties

White Solid

Uses

Ester prodrug of the ?-adrenergic agonist terbutaline

Uses

Ester prodrug of the ?2-adrenergic agonist terbutaline.

Uses

beta adrenergic agonist, bronchodilator, cholinesterase inhibitor

Definition

ChEBI: The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.

Synthesis

Conventionally, as a method for preparing bambuterol hydrochloride, bis-3,5- (N, N-dimethylcarba) is subjected to an acylation process from 3 ′, 5′-dihydroxyacetophenone represented by the following reaction formula in US Pat. No. 4419364. Preparing moyloxy) -acetophenone (step 1); Preparing a bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2-bromo-acetophenone therefrom (step 2); Preparing an bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2- (N-benzyl tert-butyl) amino-acetophenone from the alkylation process therefrom (step 3); From this step to prepare a 1- [bis- (3 ', 5'-N, N-dimethylcarbamoyloxy) phenyl] -2-N-3 tert-butylaminoethanol hydrochloride, ie bambuterol hydrochloride.