Introduction：Basic information about Befotertinib CAS 1835667-63-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Befotertinib Basic information
| Product Name: | Befotertinib |
| Synonyms: | N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-;Befotertinib;CPD0557;lung,Epidermal growth factor receptor,D0316,D 0316,ErbB-1,Inhibitor,HER1,inhibit,cancer,EGFR,kinase,tyrosine,non-small,NSCLC;Befotertinib, 10 mM in DMSO;Befotertinib (D-0316) |
| CAS: | 1835667-63-4 |
| MF: | C29H32F3N7O2 |
| MW: | 567.61 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 1835667-63-4.mol |
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Befotertinib Chemical Properties
| density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 62.5 mg/mL (110.11 mM; ultrasonic and warming and heat to 60°C) |
| pka | 12.68±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety Information
Befotertinib Usage And Synthesis
| Uses | Befotertinib (D-0316) is the third-generation EGFR tyrosine kinase inhibitor. Befotertinib can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC)[1]. |
| References | [1] Nagasaka M, et, al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC. J Thorac Oncol. 2021 May;16(5):740-763. DOI:10.1016/j.jtho.2020.11.028 |
Befotertinib Preparation Products And Raw materials
