Benzydamine hydrochloride CAS 132-69-4
Introduction：Basic information about Benzydamine hydrochloride CAS 132-69-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Benzydamine hydrochloride Basic information
| Product Name: | Benzydamine hydrochloride |
| Synonyms: | LABOTEST-BB LT00771795;BENZYDAMINE HCL;BENZYDAMINE HYDROCHLORIDE;1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE;epirotin;imotryl;indolin;n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro |
| CAS: | 132-69-4 |
| MF: | C19H23N3O.ClH |
| MW: | 345.87 |
| EINECS: | 205-076-0 |
| Product Categories: | ROBINUL;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate |
| Mol File: | 132-69-4.mol |
Benzydamine hydrochloride Chemical Properties
| Melting point | 147-153°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water, ethanol, chloroform, n-butanol or DMSO/n |
| Merck | 14,1122 |
| Major Application | forensics and toxicology pharmaceutical (small molecule) veterinary |
| InChI | InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H |
| InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC=1C(=NN2CC1C=CC=CC=1)OCCCN(C)C.Cl |
| CAS DataBase Reference | 132-69-4(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | NK7875000 |
| HS Code | 2933.99.8290 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
| Toxicity | LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini) |
| Description | Benzydamine hydrochloride is a non-steroidal antiinflammatorydrug used both topically and systemically.It has been reported as a sensitizer and aphotosensitizer and caused occupational contact dermatitisin a nurse. |
| Chemical Properties | Off-White Solid |
| Originator | Tantum,Angelini |
| Uses | A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties. |
| Uses | anticholinergic |
| Uses | A nonsteroidal anti-inflammatory with local anesthetic properties. |
| Uses | Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis. |
| Definition | ChEBI: Benzydamine hydrochloride is a member of indazoles. |
| Manufacturing Process | To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120ml of concentrated hydrochloric acid at 25°C was added concentrated solutionof 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in1.5 L of water. To this solution under nitrogen was added 400 g of sodiumbisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. Theobtained solid product was dissolved in water and then to the solution wasadded 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole 70%, M.P. 154-156°C. In practice it is usually used as monohydrochloride salt. |
| Brand name | Tantum (Angelini Francesco, Italy). |
| Therapeutic Function | Analgesic, Antiinflammatory, Antipyretic |
| Contact allergens | It is a nonsteroidal anti-inflammatory drug used bothtopically and systemically. It has been reported as asensitizer and a photosensitizer. |
| Side effects | The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration. |
| Safety Profile | Poison byintraperitoneal, subcutaneous, andintravenous routes. Moderately toxic byingestion. An experimental teratogen. Otherexperimental animal reproductive effects.An eye irritant. A nonsteroidal antiinflammatoryanalgesic. When heated todecomposition it emits very toxic fumes ofHCl and NOx. |
Benzydamine hydrochloride Preparation Products And Raw materials
| Raw materials | Water-->Sulfur dioxide-->Anthranilic acid-->2-Hydrazinobenzoic acid hydrochloride-->6,7,8-Trifluoro-1,4-dihydrogen-4-oxo-quinoline-3-carboxylate ethyl ester-->Benzydamine-->Sodium hydroxide-->Hydrochloric acid-->Sodium nitrite-->Methyl anthranilate-->1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt-->Carbon-->3-Chloro-1-(N,N-dimethyl)propylamine |
