Introduction：Basic information about beta-Cyclodextrin hydrate CAS 68168-23-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
beta-Cyclodextrin hydrate Basic information
| Product Name: | beta-Cyclodextrin hydrate |
| Synonyms: | BETA-SCHARDINGER DEXTRIN;BETA-SHARDINGER DEXTRIN;β-cyclodextrin undecahydrate;BETA-CYCLODEXTRIN HYDRATE;CD;CYCLOHEPTAAMYLOSE;CYCLOHEPTAAMYLOSE HYDRATE;á-cyclodextrin hydrate |
| CAS: | 68168-23-0 |
| MF: | C42H70O35 |
| MW: | 1134.98 |
| EINECS: | 231-493-2 |
| Product Categories: | |
| Mol File: | 68168-23-0.mol |
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beta-Cyclodextrin hydrate Chemical Properties
| Melting point | >260 °C (dec.)(lit.) |
| alpha | 161 º (c=1, H2O 25 ºC) |
| storage temp. | Refrigerator |
| solubility | Water (Slightly) |
| form | Crystalline Powder |
| color | White |
| Optical Rotation | [α]20/D +142°, c = 1 in H2O (Dry basis) |
| Water Solubility | 18.5 g/L (25 ºC) |
| Merck | 14,2718 |
| BRN | 5915513 |
| InChIKey | WHGYBXFWUBPSRW-JXMPPWEANA-N |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | GU2293000 |
| TSCA | Yes |
| HS Code | 35051000 |
| Storage Class | 11 - Combustible Solids |
beta-Cyclodextrin hydrate Usage And Synthesis
| Description | β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility. |
| Chemical Properties | white crystalline powder |
| Uses | beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents. |
| General Description | β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations. |
| Purification Methods | Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.] |
| References | [1] HOFFMAN T. Book Review: The Nicholas Effect: A Boy’s Gift to the World[J]. Journal of transplant coordination?: official publication of the North American Transplant Coordinators Organization (NATCO), 1999, 9 1: 281-281. DOI: 10.1177/090591999900900414
[2] G B WILLIAMSON J D W. Bacterial degradation of juglone?: Evidence against allelopathy?[J]. Journal of Chemical Ecology, 1990, 16 5: 1739-1742. DOI: 10.1007/bf01014105
[3] VENKATRAMANA M. RAO . Co-solubilization of poorly soluble drugs by micellization and complexation[J]. International Journal of Pharmaceutics, 2006, 319 1: Pages 98-106. DOI: 10.1016/j.ijpharm.2006.03.042 |
beta-Cyclodextrin hydrate Preparation Products And Raw materials
