Introduction：Basic information about BETONICINE CAS 515-25-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
BETONICINE Basic information
| Product Name: | BETONICINE |
| Synonyms: | trans-2-Carboxy-4-hydroxy-1,1-dimethylpyrrolidinium hydroxide, inner salt;(2S,4R)-4-Hydroxy-2-carboxylato-1,1-dimethylpyrrolidin-1-ium;4-Hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate;4-Hydroxy-stachydrine;Aids013405;Aids-013405;Nsc655264;Pyrrolidinium, 2-carboxy-4-hydroxy-1,1-dimethyl-, inner salt, (2S,4S)- |
| CAS: | 515-25-3 |
| MF: | C7H13NO3 |
| MW: | 159.18 |
| EINECS: | 208-195-6 |
| Product Categories: | Alkaloids |
| Mol File: | 515-25-3.mol |
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BETONICINE Chemical Properties
| Melting point | 246-248°C |
| alpha | D20 -34.2° (c = 1.0) |
| Boiling point | 284.67°C (rough estimate) |
| density | 1.2013 (rough estimate) |
| refractive index | 1.4760 (estimate) |
| LogP | -4.240 (est) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
BETONICINE Usage And Synthesis
| Uses | Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures[1]. |
| Definition | ChEBI: An amino-acid betaine that is trans-4-hydroxy-L-proline zwitterion in which both of the hydrogens attached to the nitrogen have been replaced by methyl groups. |
| References | [1] Bashir A, et al. Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis. Microbiology (Reading). 2014 Oct;160(Pt 10):2283-2294. DOI:10.1099/mic.0.079665-0 |
BETONICINE Preparation Products And Raw materials
| Raw materials | Iodomethane-->L-Hydroxyproline |
| Preparation Products | (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate |
