Bis(2-oxo-3-oxazolidinyl)phosphinic chloride CAS 68641-49-6

Introduction：Basic information about Bis(2-oxo-3-oxazolidinyl)phosphinic chloride CAS 68641-49-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Basic information

• Product Name: Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
• Synonyms: bis(2-oxo-3-oxazolidinyl)-phosphinicchlorid;PHOSPHORIC ACID BIS(2-OXOOXAZOLIDIDE) CHLORIDE;N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHINIC CHLORIDE;N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHONIC CHLORIDE;N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHORODIAMIDIC CHLORIDE;Bis(2-oxo-3-oxazolid;Phosphoric acid bi;Phosphoric acid bis(2-oxooxazolidide) chloride(BOP-Cl)
• CAS: 68641-49-6
• MF: C6H8ClN2O5P
• MW: 254.56
• EINECS: 629-561-5
• Product Categories: Coupling Reagent;Peptide coupling agents;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Synthetic Organic Chemistry
• Mol File: 68641-49-6.mol

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Chemical Properties

• Melting point: 191 °C (dec.)(lit.)
• Boiling point: 332.8±25.0 °C(Predicted)
• density: 1.71±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: slightly sol CH2Cl2, MeCN, THF, DMF; dec H2O
• form: Crystalline Powder
• pka: -2.47±0.20(Predicted)
• color: White to off-white
• Water Solubility: Hydrolyzes with water.
• Sensitive: Moisture Sensitive
• BRN: 3654596
• InChI: InChI=1S/C6H8ClN2O5P/c7-15(12,8-1-3-13-5(8)10)9-2-4-14-6(9)11/h1-4H2
• InChIKey: KLDLRDSRCMJKGM-UHFFFAOYSA-N
• SMILES: P(N1CCOC1=O)(N1CCOC1=O)(Cl)=O
• CAS DataBase Reference: 68641-49-6(CAS DataBase Reference)

Safety Information

• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: SZ5871000
• F: 10-21
• HazardClass: 8
• PackingGroup: II
• HS Code: 29349990
• Storage Class: 8A - Combustible corrosive hazardous materials
• Hazard Classifications: Skin Corr. 1B

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Usage And Synthesis

Description

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride is a reagent for activating carboxyl groups, converting acids to esters (including thioesters and phosphoesters), amides (including peptides and β-lactams), and anhydrides; reagent for kinetic resolution of racemic carboxylic acids and alcohols.

Chemical Properties

White solid

Uses

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride was used in the preparation of hexadepsipeptide.

storage

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride should store in a cool dry place under nitrogen to preclude contact with moisture  and oxygen. Use only in a chemical fume hood. Wear suitable protective clothing and eye/face protection.  Causes burns and is harmful if swallowed, inhaled, or absorbed through skin.

Purification Methods

the outcome of reactions can be greatly affected by the purity of the reagent; commercial samples may require to be washed with cold water and recrystallized from MeCN prior to use.