BRD0209 (BRD 0209) CAS 1597439-87-6
Introduction：Basic information about BRD0209
(BRD 0209) CAS 1597439-87-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
BRD0209(BRD 0209) Basic information
| Product Name: | BRD0209(BRD 0209) |
| Synonyms: | BRD0209(BRD 0209);BRD0209;5H-Pyrazolo[3,4-b]quinolin-5-one, 3-cyclopropyl-1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-, (4S)-;(S)-3-Cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one;BRD0209/(S)-3-Cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one;BRD0209, 10 mM in DMSO;(4S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| CAS: | 1597439-87-6 |
| MF: | C22H25N3O |
| MW: | 347.45 |
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| Mol File: | 1597439-87-6.mol |
BRD0209(BRD 0209) Chemical Properties
| form | Solid |
| color | Light yellow to yellow |
Safety Information
| Description | BRD0209 is a highly selective and potent GSK3 inhibitor. BRD0209 demonstrates in vivo efficacy in a dopaminergic signaling paradigm modeling mood-related disorders. The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3). |
| Uses | BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases[1]. |
| References | [1] Wagner FF, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-1963. DOI:10.1021/acschembio.6b00306 |
BRD0209(BRD 0209) Preparation Products And Raw materials
