Introduction：Basic information about Brodifacoum CAS 56073-10-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Brodifacoum Basic information
| Product Name: | Brodifacoum |
| Synonyms: | KLERAT;KLERAT(R);FORWARAT;HAVOC;BROBAIT;BRODIFACOUM;3-(3-(4'-bromo-(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxy-2h-1-benzopyran-2-one;3-(3-(4'-Bromo-(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-napthalenyl)-4-hydroxycoumarin |
| CAS: | 56073-10-0 |
| MF: | C31H23BrO3 |
| MW: | 523.42 |
| EINECS: | 259-980-5 |
| Product Categories: | Alphabetic;B;BI - BZPesticides&Metabolites;Pesticides;Rodenticides;A-BAlphabetic;Alpha sort;Pesticides&Metabolites;INSECTICIDE |
| Mol File: | 56073-10-0.mol |
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Brodifacoum Chemical Properties
| Melting point | 228-230° |
| Boiling point | 679.0±55.0 °C(Predicted) |
| density | 1.2940 (rough estimate) |
| vapor pressure | 41 x l0-6 Pa (20 °C) |
| refractive index | 1.4620 (estimate) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 5.0 (weak acid, est.) |
| Water Solubility | 0.24 mg l-1 (20 °C) |
| Merck | 13,1363 |
| BRN | 8171403 |
| CAS DataBase Reference | 56073-10-0(CAS DataBase Reference) |
| EPA Substance Registry System | Brodifacoum (56073-10-0) |
Safety Information
| Hazard Codes | T+;N,N,T+ |
| Risk Statements | 27/28-48/24/25-50/53 |
| Safety Statements | 1/2-36/37-45-60-61 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | GN4934750 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| Hazardous Substances Data | 56073-10-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in male, female field rats: 0.16, 0.18 mg/kg (Yuet-Ming) |
Brodifacoum Usage And Synthesis
| Description | Brodifacoum is a 4-hydroxycoumarin anticoagulant that acts asa vitamin K antagonist. It was registered as a pesticide in 1979in the United States although in 2008 it was made a restricteduse pesticide by the Environmental Protection Agency. Thismeans it can only be used by certified pesticide applicators;however, the makers of D-Con which contains 0.005% brodifacoumby weight have challenged this and brodifacoum iscurrently available in D-Con and in various other pesticideproducts for the eradication of mice and rats although it is alsoused on larger mammals such as possums. Brodifacoumcurrently remains available to the general public. |
| Chemical Properties | White Solid |
| Uses | Brodifacoum is used to control rodents in and around buildings. |
| Uses | Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides. |
| Uses | Rodenticide. |
| Definition | ChEBI: Brodifacoum is a member of benzenes, a ring assembly and a member of naphthalenes. |
| Hazard | Poison, anticoagulant. |
| Environmental Fate | Brodifacoum, like other hydroxycoumarins, interferes with theproduction of vitamin K–dependent coagulation factors.Vitamin K is a cofactor for the carboxylation of specific glutamicacid groups in coagulation factors II (prothrombin), VII,IX, and X. During this step, vitamin K is oxidized to vitamin K2,3-epoxide. The regeneration of vitamin K by vitamin K2,3-epoxide reductase is prevented by brodifacoum. As a result,dysfunctional decarboxy-coagulation factors are produced andcoagulation is impaired. Brodifacoum is over 100 times morepotent than warfarin on a molar basis in rats. |
| Metabolic pathway | The fate of brodifacoum in soils and plants has not been studied in detailbecause the compound is usually applied as a pelleted bait or in a waxblock. This limits its dissipation in the environment. Studies in animalshave been conducted as part of the assessment of safety and to investigatemode of action. |
| Degradation | Brodifacoum is a stable compound; no detectable degradation occurs at50 °C or in direct sunlight over 30 days, though it is liable to some photodecompositionin solution. |
| Toxicity evaluation | Brodifacoum has a very low solubility in water and typicallyenters water through erosion where it is then found in thesediment. Brodifacoum concentrations are typically notmeasurable in water systems.
Products that contain brodifacoum as pesticide can remaintoxic for a long period of time in the environment. The rate ofdecay of brodifacoum depends upon the amount of rainfall. Asthe product that contains brodifacoum degrades over time, thebrodifacoum is absorbed into the soil. Soil bacteria degradebrodifacoum over weeks to months although soil type,temperature, and the presence of microorganisms that willdegrade brodifacoum all influence the time it takes to degrade. |
Brodifacoum Preparation Products And Raw materials
| Raw materials | Potassium hydroxide-->Polyphosphoric acid-->Diethyl malonate-->Phosphorus tribromide-->Potassium borohydride-->4-Hydroxycoumarin-->Phenylacetyl chloride-->4-Bromobiphenyl-->1,2,3,4-Tetrahydro-1-naphthol |
