Bromocresol green CAS 76-60-8
Introduction：Basic information about Bromocresol green CAS 76-60-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Bromocresol green Basic information
| Product Name: | Bromocresol green |
| Synonyms: | Phenol,4,4’-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-,S,S-dioxide;tetrabromo-m-cresolphthaleinsulfone;vertdebromocresol;BACILLUS OF CALMETTE AND GUERIN;BCG;BROMCRESOL GREEN;BROMOCRESOL GREEN SULTONE FORM;BROMOCRESOL BLUE |
| CAS: | 76-60-8 |
| MF: | C21H14Br4O5S |
| MW: | 698.01 |
| EINECS: | 200-972-8 |
| Product Categories: | Sulfonephthalein;Flavones, Flavonoids, FoodstuffsDerivatization Reagents TLC;Organic Acids, Carboxylic AcidsDerivatization Reagents;Derivatization Reagents TLC;TLC Reagents, A-C;TLC ReagentsDerivatization Reagents TLC;TLC Visualization Reagents (alphabetic sort);B;Stains and Dyes;Stains&Dyes, A to;Organics;TLC Stains;Analytical Chemistry;Indicator (pH);pH Indicators;TLC Visualization Reagents (by application);AR;76-60-8 |
| Mol File: | 76-60-8.mol |
Bromocresol green Chemical Properties
| Melting point | 225 °C (dec.) (lit.) |
| bulk density | 350kg/m3 |
| density | 0.79 g/mL at 20 °C |
| Fp | 12 °C |
| storage temp. | no restrictions. |
| solubility | Solubility Sparingly soluble in water; soluble in ethanol, ether, ethyl acetate |
| pka | 4.7(at 25℃) |
| form | Powder/Solid |
| Boiling point | 626.0±55.0 °C(Predicted) |
| color | Pale orange |
| PH | 3.8～5.4 |
| PH Range | 3.8(YELLOW)-5.4(BLUE) |
| Water Solubility | slightly soluble |
| λmax | 423nm, 444nm, 617nm |
| Merck | 14,1386 |
| BRN | 372527 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Major Application | Sol-gel matrix, fuel cells, sensors, display device, inks, paints, one-steptester for ammonia, cosmet-tester for ammonia, packaging system, textiles, cleansing products, detergents, cosmetics, diapers, identifying fresh and stale rice, monitoring fish spoilage, detecting carbohydrates, lacting acid bacteria, treating neoplasms, cancer, vaginal infection test method, drugs, dental materials |
| Cosmetics Ingredients Functions | COLORANT |
| InChI | 1S/C21H14Br4O5S/c1-9-12(7-14(22)19(26)17(9)24)21(13-8-15(23)20(27)18(25)10(13)2)11-5-3-4-6-16(11)31(28,29)30-21/h3-8,26-27H,1-2H3 |
| InChIKey | FRPHFZCDPYBUAU-UHFFFAOYSA-N |
| SMILES | Cc1c(Br)c(O)c(Br)cc1C2(OS(=O)(=O)c3ccccc23)c4cc(Br)c(O)c(Br)c4C |
| LogP | 7.800 (est) |
| CAS DataBase Reference | 76-60-8(CAS DataBase Reference) |
| EPA Substance Registry System | Bromcresol green (76-60-8) |
Safety Information
| Hazard Codes | F,Xi,Xn |
| Risk Statements | 11-36-67-36/37/38-20/21/22 |
| Safety Statements | 7-16-24/25-26-37/39-36 |
| RIDADR | UN 1219 3/PG 2 |
| WGK Germany | 3 |
| RTECS | SJ7456000 |
| Autoignition Temperature | 399 °C |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Chemical Properties | tan to yellow crystals |
| Uses | As indicator, pH 3.8 yellow; pH 5.4 blue-green. |
| Uses | Bromocresol Green is a pH sensitive indicator used in the growth medium for microorganisms and titrations. It is useful in various colorimetric detection studies and as an actively tracking dye for DNA agarose gel electrophoresis. It acts as an inhibitor of prostaglandin E2 transport protein. It is also used in TLC for visualizing compounds containing functional groups having pKa less than 5. |
| Uses | Bromocresol Green (BCG) is a pH sensitive triphenylmethane dye useful in a variety of colorimetric detection technologies. BCG is used as a tracking dye for DNA agarose gel electrophoresis, in protein determinations and in charge-transfer complexation processes. In TLC BCG is used for visualisation of the compounds with functional groups whose pKa is below 5.0. |
| Definition | ChEBI: Bromocresolgreen is a member of benzofurans. |
| Hazard | Moderately toxic. |
| Synthesis | A method of preparing bromocresol green in the following steps: (1) 1.5 kg of bromine is dissolved in 1.25 liters of glacial acetic acid solution to obtain a bromine-glacial acetic acid mixture; (2) 2 kg of pure m-cresol violet is dissolved in a solution of 2.5 liters of glacial acetic acid; (3) The bromine-ice acetic acid mixture obtained in step (1) is slowly dripped into the solution in step (2) at a temperature not exceeding 80?? C. After addition, stirring is continued and kept at 80 to 90?? C. for 24 hours, and then filtered after cooling down, and the precipitate is washed twice with ice acetic acid, dried or pumped, and dried at 50 to 60?? C. to obtain the crude bromocresol green. Moreover, the crude bromocresol green was recrystallized with benzene or glacial acetic acid to obtain pure bromocresol green, which crystallized into white, melting point 218-9??C. |
| Purification Methods | Crystallise the dye from glacial acetic acid or dissolve it in aqueous 5% NaHCO3 solution and precipitate it from the hot solution by dropwise addition of aqueous HCl. Repeat this until the UV/VIS-extinction did not increase 423nm. It is an indicator: at pH 3.81 at max (yellow) and pH 5.4 (blue-green). [Beilstein 19/3 V 460.] |
Bromocresol green Preparation Products And Raw materials
| Preparation Products | 2-AMINOCYCLOHEXANECARBONITRILE-->Sulphur yellow 2-->DIRECT YELLOW 28-->Leuco Sulphur Yellow 2 |
