Introduction：Basic information about CASTICIN CAS 479-91-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
CASTICIN Basic information
| Product Name: | CASTICIN |
| Synonyms: | CASTICIN;5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE;3',5-DIHYDROXY-3,4',6,7-TETRAMETHOXY FLAVONE;VITEXICARPIN;VITEXICARPIM;Casticin (Vitexicarpin);Casticin (25 mg);CASTICIN WITH HPLC |
| CAS: | 479-91-4 |
| MF: | C19H18O8 |
| MW: | 374.34 |
| EINECS: | |
| Product Categories: | Hexa-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 479-91-4.mol |
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CASTICIN Chemical Properties
| Melting point | 186-187 °C |
| Boiling point | 617.7±55.0 °C(Predicted) |
| density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble1mg/mL, clear, colorless to light yellow |
| form | Solid |
| pka | 6.13±0.40(Predicted) |
| color | Yellow |
| BRN | 1300392 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3 |
| InChIKey | PJQLSMYMOKWUJG-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(OC)C(O)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1OC |
| CAS DataBase Reference | 479-91-4(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
CASTICIN Usage And Synthesis
| Chemical Properties | Soluble in a mixed solvent of DMSO, chloroform and methanol, insoluble in petroleum ether and chloroform. Derived from the Umbelliferae plant Foeniculum vulgare |
| Uses | Casticin is a biological compound known to induce human glioma cell death through an apoptotic mechanism and disruption of the mitotic cycle. |
| Definition | ChEBI: A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. |
| in vivo | Casticin (20 mg/kg, p.o.) has toxic effect on the liver in mice with CCl4-and BDL-induced hepatic injury. Casticin attenuates liver fibrosis induced by CCl4 or BDL in vivo. Casticin inhibits HSC activation and collagen matrix expression by blocking TGF-β/Smad signaling in vivo[2]. |
CASTICIN Preparation Products And Raw materials
