Ceftiofur hydrochloride CAS 103980-44-5

Introduction：Basic information about Ceftiofur hydrochloride CAS 103980-44-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ceftiofur hydrochloride Basic information

• Product Name: Ceftiofur hydrochloride
• Synonyms: CEFTIOFUR HCL;CEFTIOFUR HYDROCHLORIDE;U-67279A;(6r-(6alpha,7beta(z))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride;(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo, monohydrochloride, (6R,7R);U 64279A;Unii-6822A07436
• CAS: 103980-44-5
• MF: C19H18ClN5O7S3
• MW: 560.01
• EINECS: 600-507-2
• Product Categories: cephalosporins;Heterocycles;Sulfur & Selenium Compounds;Pharmaceutical intermediate;Antibiotics;Inhibitors;cephalosporins antibiotics;Intermediates & Fine Chemicals;Pharmaceuticals;103980-44-5
• Mol File: 103980-44-5.mol

Ceftiofur hydrochloride Chemical Properties

• Melting point: >190°C (dec.)
• alpha: -92～-98°(D/20℃)(c=0.2,CH3OH)
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: Off-White
• Major Application: forensics and toxicology pharmaceutical (small molecule)
• InChIKey: KEQFDTJEEQKVLM-JUODUXDSSA-N
• SMILES: C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC(C1OC=CC=1)=O)(=O)O.Cl |&1:5,7,r|

Safety Information

• WGK Germany: 3
• HS Code: 2941906000
• Storage Class: 11 - Combustible Solids

Ceftiofur hydrochloride Usage And Synthesis

Brand Name(s) in US

Excenel

Description

Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Chemical Properties

Off-White Solid

Uses

Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8–10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3–5 mg/kg body weight (BW) administered intramuscularly once daily for 3–5 consecutive days.

Uses

An antibacterial.

Application

Ceftiofur hydrochloride is used for the treatment and control of infections in cattle and pigs caused by susceptible pathogens. It is approved for the treatment of bovine respiratory disease caused by Bartonella mansoni, Bartonella multocida and Bartonella somniferum (formerly Bartonella somniferum).
Ceftiofur hydrochloride is also used for the treatment of bovine interdigital necrotizing bacillosis (rotten foot disease) caused by Fusobacterium necrophorum or Bacteroides melaninogenicus. Ceftiofur hydrochloride has been shown to be effective at a dose of 2.2 mg/kg for the treatment of acute postpartum onychomycosis in dairy cows or by intrauterine instillation (1 g) for the treatment of retained foetal membranes.
Ceftiofur hydrochloride can be used for the treatment of SRD caused by Actinobacillus, Plasmodium multocida, Salmonella cholera and Streptococcus suis.Ceftiofur hydrochloride and ceftiofur amorphous acid can also be administered via the intra-udder route in dairy cows. For intramammary use, a specific formulation (Spectramast DC) is recommended. Although ceftiofur sodium has been used to treat infections in horses and dogs, there is little experience with the administration of ceftiofur sodium hydrochloride in these species.

Veterinary Drugs and Treatments

In swine, ceftiofur HCl injection is labeled for the treatment andcontrol of swine bacterial respiratory disease (swine bacterialpneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae,Pasteurella multocida, Salmonella choleraesuis andStreptococcus suis.
In cattle, ceftiofur HCl is labeled for the treatment of the followingbacterial diseases: Bovine respiratory disease (BRD, shippingfever, pneumonia) associated with Mannheimia haemolytica,Pasteurella multocida, and Histophilus somni; Acute bovine interdigitalnecrobacillosis (foot rot, pododermatitis) associated withFusobacterium necrophorum and Bacteroides melaninogenicus; andacute metritis (0 – 14 days post-partum) associated with bacterialorganisms susceptible to ceftiofur.
The intramammary syringe for dry dairy cattle (SpectramastDC?) is labeled for the treatment of subclinical mastitis in dairycattle at the time of dry off associated with Staphylococcus aureus,Streptococcus dysgalactiae, and Streptococcus uberis. The intramammarysyringe for lactating dairy cattle (Spectramast LC?) is labeledfor the treatment of clinical mastitis in lactating dairy cattle associatedwith coagulase-negative staphylococci, Streptococcus dysgalactiae,and Escherichia coli.

Toxics Screening Level

The initial threshold screening level (ITSL) for Ceftiofur Hydrochloride is 166 μg/m3 based on an annual averaging time.